A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Kenza Mamouni, Shumin Zhang, Xin Li, Yanhua Chen, Yang Yang, Jaeah Kim, Michael G. Bartlett, Ilsa M. Coleman, Peter S. Nelson, Omer Kucuk, Daqing Wu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa in preclinical models. The three ingredients of ProFine demonstrated synergistic in vitro cytotoxicity and effectively induced apoptosis in PCa cells. ProFine markedly affected the transcriptome of PCa cells, suppressed the expression of androgen receptor, and inhibited androgen-regulated genes. Oral administration of ProFine did not exhibit obvious toxicities in mice, and the three ingredients retained their individual pharmacokinetic and bioavailability profiles. Importantly, ProFine significantly retarded the growth of PCa xenografts in athymic nude mice and extended the survival of animals. This study provides preclinical evidence supporting the promise of ProFine as a safe, efficacious, and affordable intervention to control PCa progression and improve clinical outcomes.

Original languageEnglish (US)
Pages (from-to)789-799
Number of pages11
JournalNeoplasia (United States)
Volume20
Issue number8
DOIs
StatePublished - Aug 2018

ASJC Scopus subject areas

  • Cancer Research

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    Mamouni, K., Zhang, S., Li, X., Chen, Y., Yang, Y., Kim, J., Bartlett, M. G., Coleman, I. M., Nelson, P. S., Kucuk, O., & Wu, D. (2018). A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models. Neoplasia (United States), 20(8), 789-799. https://doi.org/10.1016/j.neo.2018.06.003