TY - JOUR
T1 - A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models
AU - Mamouni, Kenza
AU - Zhang, Shumin
AU - Li, Xin
AU - Chen, Yanhua
AU - Yang, Yang
AU - Kim, Jaeah
AU - Bartlett, Michael G.
AU - Coleman, Ilsa M.
AU - Nelson, Peter S.
AU - Kucuk, Omer
AU - Wu, Daqing
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/8
Y1 - 2018/8
N2 - The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa in preclinical models. The three ingredients of ProFine demonstrated synergistic in vitro cytotoxicity and effectively induced apoptosis in PCa cells. ProFine markedly affected the transcriptome of PCa cells, suppressed the expression of androgen receptor, and inhibited androgen-regulated genes. Oral administration of ProFine did not exhibit obvious toxicities in mice, and the three ingredients retained their individual pharmacokinetic and bioavailability profiles. Importantly, ProFine significantly retarded the growth of PCa xenografts in athymic nude mice and extended the survival of animals. This study provides preclinical evidence supporting the promise of ProFine as a safe, efficacious, and affordable intervention to control PCa progression and improve clinical outcomes.
AB - The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa in preclinical models. The three ingredients of ProFine demonstrated synergistic in vitro cytotoxicity and effectively induced apoptosis in PCa cells. ProFine markedly affected the transcriptome of PCa cells, suppressed the expression of androgen receptor, and inhibited androgen-regulated genes. Oral administration of ProFine did not exhibit obvious toxicities in mice, and the three ingredients retained their individual pharmacokinetic and bioavailability profiles. Importantly, ProFine significantly retarded the growth of PCa xenografts in athymic nude mice and extended the survival of animals. This study provides preclinical evidence supporting the promise of ProFine as a safe, efficacious, and affordable intervention to control PCa progression and improve clinical outcomes.
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U2 - 10.1016/j.neo.2018.06.003
DO - 10.1016/j.neo.2018.06.003
M3 - Article
C2 - 29981500
AN - SCOPUS:85049860330
SN - 1522-8002
VL - 20
SP - 789
EP - 799
JO - Neoplasia (United States)
JF - Neoplasia (United States)
IS - 8
ER -