A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs

Heng Xu; Yan Na Tian; Bo Ying Dun; Hai Tao Liu; Guang Kuo Dong; Jin Hua Wang; Shang Su Lu; Bo Chen; Jin Xiong She

doi:10.7314/APJCP.2014.15.11.4423

A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs

Heng Xu, Yan Na Tian, Bo Ying Dun, Hai Tao Liu, Guang Kuo Dong, Jin Hua Wang, Shang Su Lu, Bo Chen, Jin Xiong She

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

Original language	English (US)
Pages (from-to)	4423-4428
Number of pages	6
Journal	Asian Pacific Journal of Cancer Prevention
Volume	15
Issue number	11
DOIs	https://doi.org/10.7314/APJCP.2014.15.11.4423
State	Published - 2014

Keywords

Apoptosis
Cancer
Chemotherapy
Drug synergy
Monoclonal antibody

ASJC Scopus subject areas

Epidemiology
Oncology
Public Health, Environmental and Occupational Health
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7314/APJCP.2014.15.11.4423

Cite this

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title = "A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs",

abstract = "A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.",

keywords = "Apoptosis, Cancer, Chemotherapy, Drug synergy, Monoclonal antibody",

author = "Heng Xu and Tian, {Yan Na} and Dun, {Bo Ying} and Liu, {Hai Tao} and Dong, {Guang Kuo} and Wang, {Jin Hua} and Lu, {Shang Su} and Bo Chen and She, {Jin Xiong}",

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pages = "4423--4428",

journal = "Asian Pacific Journal of Cancer Prevention",

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T1 - A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs

AU - Xu, Heng

AU - Tian, Yan Na

AU - Dun, Bo Ying

AU - Liu, Hai Tao

AU - Dong, Guang Kuo

AU - Wang, Jin Hua

AU - Lu, Shang Su

AU - Chen, Bo

AU - She, Jin Xiong

PY - 2014

Y1 - 2014

N2 - A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

AB - A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

KW - Apoptosis

KW - Cancer

KW - Chemotherapy

KW - Drug synergy

KW - Monoclonal antibody

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A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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