A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs

Heng Xu, Yan Na Tian, Bo Ying Dun, Hai Tao Liu, Guang Kuo Dong, Jin Hua Wang, Shang Su Lu, Bo Chen, Jin Xiong She

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

Original languageEnglish (US)
Pages (from-to)4423-4428
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number11
DOIs
StatePublished - 2014

Keywords

  • Apoptosis
  • Cancer
  • Chemotherapy
  • Drug synergy
  • Monoclonal antibody

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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