@article{4c75f72a67dd4f558399a7eb5ae5ba94,
title = "A Pilot Randomized Controlled Trial Evaluating Essential Oils for Chemotherapy-Induced Peripheral Neuropathy",
abstract = "Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful, debilitating consequence of cancer treatment affecting up to 60% of patients. Pharmacological approaches to CIPN are often ineffective and cause adverse effects. Essential oils are an underutilized non-pharmacological approach to pain reduction. Aims: To ascertain the efficacy of an essential oil intervention to reduce CIPN. Design: A single-blind, pilot randomized controlled trial. Methods: Participants (n = 27) were stratified by baseline pain scores and randomized to intervention (n = 13) and placebo groups (n = 14). Participants topically-applied the essential oil intervention or placebo every eight hours for six weeks. Pain was assessed using the Short-Form-McGill Pain Questionnaire-2 weekly and the Visual Analogue Scale daily. Quality-of-life was assessed using the Quality-of-Life: CIPN-20 and Quality-of-Life Adult Cancer Survivor questionnaires. Data were analyzed in SPSS using generalized estimating equations. Results: No significant difference was observed between groups in pain or quality-of-life scores over seven weeks, but improvement was observed in both groups. Participants using the intervention with pain medications showed a significant reduction in pain compared to placebo (p = .001). Educational level (p = .041) and annual income (p = .005) were significant covariates mirroring these social determinates of pain. Older participants felt less negatively about their CIPN (p = .002). Positive placebo effect and spatiotemporal interactions were observed. Conclusions: This pilot study demonstrated that participants adhered to the intervention for six weeks. Essential oils have potential direct and adjuvant pain-reducing effects and should be studied further.",
author = "Langley-Brady, {Dawn L.} and Campbell, {Richard T.} and Maihle, {Nita J.} and Barnes, {Vernon A.} and Bratton, {Angela R.} and Zadinsky, {Julie K.}",
note = "Funding Information: This work was supported by the American Holistic Nurses Association ( AHNA 2017 Research Grant), the Sigma Theta Tau International/American Nurses Foundation ( STTI/ANF 2017 Research Grant), the Augusta University Center for Undergraduate Research and Scholarship ( 2018 Equipment Grant), and donations and discounts from Ananda Apothecary (Denver, CO), The Jojoba Company (Waldoboro, ME), and the Container and Packaging Supply Company (Eagle, ID). Please note that funding sources and businesses had no other roles in this study. Funding Information: This work was supported by the American Holistic Nurses Association (AHNA 2017 Research Grant), the Sigma Theta Tau International/American Nurses Foundation (STTI/ANF 2017 Research Grant), the Augusta University Center for Undergraduate Research and Scholarship (2018 Equipment Grant), and donations and discounts from Ananda Apothecary (Denver, CO), The Jojoba Company (Waldoboro, ME), and the Container and Packaging Supply Company (Eagle, ID). Please note that funding sources and businesses had no other roles in this study. The corresponding author received conference presentation honorariums and travel grants. She was the sole proprietor of Aromatherapeutic Solutions in Augusta, GA. She is in consultation with the Augusta University Office of Innovation and Commercialization about potential commercial pathways for this study's essential oil intervention. We are thankful to our funding sources, the American Holistic Nurses Association and American Nurses Foundation/Sigma Theta Tau International, along with discounts from Ananda Apothecary and The Jojoba Company. We are grateful to the university's Center for Undergraduate Research and Scholarship; former student assistants Ian Burau, Brenda Nelson, and Michael Jones-Asgill; the Clinical Research Pharmacy Manager, Marjorie Phillips; the Center for Nursing Research, Chelsey Lemons and Keith Williams; the CON Center for Strategic Initiatives, Dr. Dwayne Hooks, Jennifer Brassell, and Tracy Brickey; the Nurse-Managed Health Center, Dr. Tranika Brown and Racquel; the Cancer Center, Dr. Allan Krutchik and Dr. Alicia Vinyard; the Breast Health Center, Melissa Manley, and Sloan Maes; and, most importantly, our study participants. Publisher Copyright: {\textcopyright} 2023 American Society for Pain Management Nursing",
year = "2023",
month = jan,
doi = "10.1016/j.pmn.2022.12.008",
language = "English (US)",
journal = "Pain Management Nursing",
issn = "1524-9042",
publisher = "W.B. Saunders Ltd",
}
