A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru

Molly C. Visser; Dennis Ownby; Manuel Aguilar-Villalobos; Larry L. Needham; Luke P. Naeher

doi:10.1016/j.envint.2006.08.009

A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru

Molly C. Visser, Dennis Ownby, Manuel Aguilar-Villalobos, Larry L. Needham, Luke P. Naeher

Allergy-Immunology and Rheumatology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: This November 2003 pilot study investigates the correlation between serum IgE and residential endotoxin levels from a group of 18 pregnant women living in Trujillo, Peru, and investigates the impact of the demographic and lifestyle factors of this group on the IgE and endotoxin levels measured. Methods: Serum samples were collected from 19 subjects and analyzed for IgE. Dust samples were collected from the mattresses of 18 subjects and measured for endotoxin levels. A questionnaire was used to obtain demographic, socioeconomic, and lifestyle information for each subject. Results: Geometric means for IgE and endotoxin were 246.8 (GSD = 4.3, n = 19) IU/mL and 66.5 EU/mg (GSD = 1.7, n = 18), respectively. Log-transformed IgE and endotoxin were not correlated (R² = 0.02; p = 0.60). Conclusions: Residential endotoxin and serum IgE were not correlated in this group. Potential selection bias and sample size are major limitations of the study. However, 74% (14/19) of the subjects in this study had an IgE over 100 IU/mL, a level generally considered elevated.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Environment international
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.envint.2006.08.009
State	Published - Feb 2007

Keywords

Developing world
Endotoxin
IgE
Peru
Pregnant women

ASJC Scopus subject areas

Environmental Science(all)

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10.1016/j.envint.2006.08.009

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@article{d9a20ade71ed4d86b98a388ff7e5ff06,

title = "A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru",

abstract = "Objective: This November 2003 pilot study investigates the correlation between serum IgE and residential endotoxin levels from a group of 18 pregnant women living in Trujillo, Peru, and investigates the impact of the demographic and lifestyle factors of this group on the IgE and endotoxin levels measured. Methods: Serum samples were collected from 19 subjects and analyzed for IgE. Dust samples were collected from the mattresses of 18 subjects and measured for endotoxin levels. A questionnaire was used to obtain demographic, socioeconomic, and lifestyle information for each subject. Results: Geometric means for IgE and endotoxin were 246.8 (GSD = 4.3, n = 19) IU/mL and 66.5 EU/mg (GSD = 1.7, n = 18), respectively. Log-transformed IgE and endotoxin were not correlated (R2 = 0.02; p = 0.60). Conclusions: Residential endotoxin and serum IgE were not correlated in this group. Potential selection bias and sample size are major limitations of the study. However, 74% (14/19) of the subjects in this study had an IgE over 100 IU/mL, a level generally considered elevated.",

keywords = "Developing world, Endotoxin, IgE, Peru, Pregnant women",

author = "Visser, {Molly C.} and Dennis Ownby and Manuel Aguilar-Villalobos and Needham, {Larry L.} and Naeher, {Luke P.}",

note = "Funding Information: Funding: International Society of Exposure Analysis/American Chemistry Council Early Career Award, University of Georgia, Biomedical Health Sciences Institute (BSHI), Office of International Agriculture, and Interdisciplinary Toxicology Program. Funding Information: We thank all the subjects who participated in our study. Thanks also go to Trujillo City Hall, Ing. Jose Murgia Zannier, Major of Trujillo, Tona Aguilar, Agustin Asmad, and Luz Marina Angeles for their field work support in Trujillo. We also thank the UGA Biomedical Health Sciences Institute, UGA CAES Office of International Agriculture, and UGA Interdisciplinary Toxicology Program for their financial support. Thanks also go to Brandon Cassidy from UGA and Charles Dodson from CDC/NCEH for help with the field work for this study.",

year = "2007",

month = feb,

doi = "10.1016/j.envint.2006.08.009",

language = "English (US)",

volume = "33",

pages = "147--150",

journal = "Environmental International",

issn = "0160-4120",

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T1 - A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru

AU - Visser, Molly C.

AU - Ownby, Dennis

AU - Aguilar-Villalobos, Manuel

AU - Needham, Larry L.

AU - Naeher, Luke P.

N1 - Funding Information: Funding: International Society of Exposure Analysis/American Chemistry Council Early Career Award, University of Georgia, Biomedical Health Sciences Institute (BSHI), Office of International Agriculture, and Interdisciplinary Toxicology Program. Funding Information: We thank all the subjects who participated in our study. Thanks also go to Trujillo City Hall, Ing. Jose Murgia Zannier, Major of Trujillo, Tona Aguilar, Agustin Asmad, and Luz Marina Angeles for their field work support in Trujillo. We also thank the UGA Biomedical Health Sciences Institute, UGA CAES Office of International Agriculture, and UGA Interdisciplinary Toxicology Program for their financial support. Thanks also go to Brandon Cassidy from UGA and Charles Dodson from CDC/NCEH for help with the field work for this study.

PY - 2007/2

Y1 - 2007/2

N2 - Objective: This November 2003 pilot study investigates the correlation between serum IgE and residential endotoxin levels from a group of 18 pregnant women living in Trujillo, Peru, and investigates the impact of the demographic and lifestyle factors of this group on the IgE and endotoxin levels measured. Methods: Serum samples were collected from 19 subjects and analyzed for IgE. Dust samples were collected from the mattresses of 18 subjects and measured for endotoxin levels. A questionnaire was used to obtain demographic, socioeconomic, and lifestyle information for each subject. Results: Geometric means for IgE and endotoxin were 246.8 (GSD = 4.3, n = 19) IU/mL and 66.5 EU/mg (GSD = 1.7, n = 18), respectively. Log-transformed IgE and endotoxin were not correlated (R2 = 0.02; p = 0.60). Conclusions: Residential endotoxin and serum IgE were not correlated in this group. Potential selection bias and sample size are major limitations of the study. However, 74% (14/19) of the subjects in this study had an IgE over 100 IU/mL, a level generally considered elevated.

AB - Objective: This November 2003 pilot study investigates the correlation between serum IgE and residential endotoxin levels from a group of 18 pregnant women living in Trujillo, Peru, and investigates the impact of the demographic and lifestyle factors of this group on the IgE and endotoxin levels measured. Methods: Serum samples were collected from 19 subjects and analyzed for IgE. Dust samples were collected from the mattresses of 18 subjects and measured for endotoxin levels. A questionnaire was used to obtain demographic, socioeconomic, and lifestyle information for each subject. Results: Geometric means for IgE and endotoxin were 246.8 (GSD = 4.3, n = 19) IU/mL and 66.5 EU/mg (GSD = 1.7, n = 18), respectively. Log-transformed IgE and endotoxin were not correlated (R2 = 0.02; p = 0.60). Conclusions: Residential endotoxin and serum IgE were not correlated in this group. Potential selection bias and sample size are major limitations of the study. However, 74% (14/19) of the subjects in this study had an IgE over 100 IU/mL, a level generally considered elevated.

KW - Developing world

KW - Endotoxin

KW - IgE

KW - Peru

KW - Pregnant women

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JF - Environmental International

SN - 0160-4120

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ER -

A pilot study to assess residential endotoxin and blood IgE in a group of pregnant women from Trujillo, Peru

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