A potential donor gene for the bm1 gene conversion event in the C57BL mouse

A. L. Mellor, E. H. Weiss, K. Ramachandran, R. A. Flavell

Research output: Contribution to journalArticle

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Abstract

The mammalian major histocompatibility complex (MHC; H-2 complex in mouse) is a large multigene complex which encodes cell-surface antigens involved in the cellular immune response to foreign antigens1. Class I polypeptides expressed at the H-2K and H-2D (Fig. 1) loci of numerous mouse strains exhibit an unusually high degree of genetic polymorphism, which is assumed to be related to their function as primary recognition elements in the immune response. We suggested that this H-2 polymorphism may arise by gene conversion-like events between non-allelic class I genes. This is supported by our recent comparison of the DNA sequences of the normal H-2Kb gene sequence, from the C57BL/10 mouse, and a mutant2,3 form of this gene called H-2K bm1 (ref. 4): the mutant allele differs from the H-2Kb gene in seven bases out of a region of 13 bases in exon 3 of the class I gene (which encodes α2 (C1) the second highly polymorphic protein domain), suggesting that this region of new sequence had been introduced into the H-2Kb sequence following unequal pairing of two class I genes in the genome of the C57BL mouse. Schulze et al. have obtained similar results 5. Here we report work identifying a potential donor gene in our library of 26 class I genes cloned from the C57BL/10 mouse.

Original languageEnglish (US)
Pages (from-to)792-795
Number of pages4
JournalNature
Volume306
Issue number5945
DOIs
StatePublished - Dec 1 1983

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MHC Class I Genes
Gene Conversion
Inbred C57BL Mouse
Genes
Genetic Polymorphisms
Surface Antigens
Major Histocompatibility Complex
Cellular Immunity
Exons
Alleles
Genome
Peptides

ASJC Scopus subject areas

  • General

Cite this

Mellor, A. L., Weiss, E. H., Ramachandran, K., & Flavell, R. A. (1983). A potential donor gene for the bm1 gene conversion event in the C57BL mouse. Nature, 306(5945), 792-795. https://doi.org/10.1038/306792a0

A potential donor gene for the bm1 gene conversion event in the C57BL mouse. / Mellor, A. L.; Weiss, E. H.; Ramachandran, K.; Flavell, R. A.

In: Nature, Vol. 306, No. 5945, 01.12.1983, p. 792-795.

Research output: Contribution to journalArticle

Mellor, AL, Weiss, EH, Ramachandran, K & Flavell, RA 1983, 'A potential donor gene for the bm1 gene conversion event in the C57BL mouse', Nature, vol. 306, no. 5945, pp. 792-795. https://doi.org/10.1038/306792a0
Mellor AL, Weiss EH, Ramachandran K, Flavell RA. A potential donor gene for the bm1 gene conversion event in the C57BL mouse. Nature. 1983 Dec 1;306(5945):792-795. https://doi.org/10.1038/306792a0
Mellor, A. L. ; Weiss, E. H. ; Ramachandran, K. ; Flavell, R. A. / A potential donor gene for the bm1 gene conversion event in the C57BL mouse. In: Nature. 1983 ; Vol. 306, No. 5945. pp. 792-795.
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