A preliminary report of the effects of orally administered enoximone on regional hemodynamics in congestive heart failure

Carl V. Leier, Steffen E.L. Meiler, Sally Matthews, Donald V. Unverferth

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Twelve patients with moderately severe congestive heart failure underwent the simultaneous determination of central and regional hemodynamics after administration of placebo and enoximone. The regions examined hemodynamically included renal, hepatics-planchnic and upper limb. Enoximone was studied in 2 doses, 1 and 2 mg/kg, and administered in a double-blind, placebo-controlled, crossover design. At these doses enoximone elicited a significantly greater increase in cardiac output and a greater decrease in systemic vascular resistance than placebo. Systemic blood pressure was not significantly altered. Enoximone did not significantly change the flow or resistance of renal or hepatic-splanchnic vascular beds. Limb vascular resistance decreased modestly after enoximone with a significant augmentation (+12% to 17%) of limb blood flow compared with placebo. The initial oral administration of the 1 and 2 mg/kg doses of enoximone improved central hemodynamic parameters with apparent preferential reduction of limb vascular resistance and augmentation of blood flow to the limb region (peripheral musculoskeletal system).

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalThe American Journal of Cardiology
Volume60
Issue number5
DOIs
StatePublished - Aug 14 1987

Fingerprint

Enoximone
Heart Failure
Hemodynamics
Extremities
Placebos
Vascular Resistance
Kidney
Musculoskeletal System
Viscera
Liver
Upper Extremity
Cardiac Output
Cross-Over Studies
Blood Vessels
Oral Administration
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A preliminary report of the effects of orally administered enoximone on regional hemodynamics in congestive heart failure. / Leier, Carl V.; Meiler, Steffen E.L.; Matthews, Sally; Unverferth, Donald V.

In: The American Journal of Cardiology, Vol. 60, No. 5, 14.08.1987, p. 27-30.

Research output: Contribution to journalArticle

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