Abstract
Aqueous extract of Clerodendron glandulosum. Coleb (CG) (400 mg/kg/day) was orally administered to rats rendered hyperlipidemic chronically (by feeding high-fat diet; HL) to assess its possible lipid-lowering potential. The hyperlipidemic rats were administered CG extract by oral gavage from 30-90 days along with high fat diet. Plasma lipid profile was monitored on 30th, 60th and 90th days to assess the effect of CG extract. Observations revealed a decrement in body weight (9.6%), plasma TC (15.63%), TG (42.99%), PL (13.91%), LDL-C (81.36%) and VLDL-C (43%) along with an increase in HDL-C (52.84%) at 90 days (after 60 days of CG extract feeding) compared to high levels at 30 days. Fecal lipid analysis revealed high content of TC, TG and PL in HL + CG group. Lipid-lowering property of the CG extract in chronic hyperlipidemic rats validates its use traditionally as a part of folklore medicine in North-eastern India, though there is no scientific evaluation to date.
Original language | English (US) |
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Pages (from-to) | 285-289 |
Number of pages | 5 |
Journal | International Journal of Green Pharmacy |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2009 |
Externally published | Yes |
Keywords
- Cholesterol
- Clerodendron glandulosum. Coleb
- Hyperlipidemia
- Lipoproteins
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science