A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.Coleb

R. N. Jadeja, M. C. Thounaojam, Ansarullah, R. V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Aqueous extract of Clerodendron glandulosum. Coleb (CG) (400 mg/kg/day) was orally administered to rats rendered hyperlipidemic chronically (by feeding high-fat diet; HL) to assess its possible lipid-lowering potential. The hyperlipidemic rats were administered CG extract by oral gavage from 30-90 days along with high fat diet. Plasma lipid profile was monitored on 30th, 60th and 90th days to assess the effect of CG extract. Observations revealed a decrement in body weight (9.6%), plasma TC (15.63%), TG (42.99%), PL (13.91%), LDL-C (81.36%) and VLDL-C (43%) along with an increase in HDL-C (52.84%) at 90 days (after 60 days of CG extract feeding) compared to high levels at 30 days. Fecal lipid analysis revealed high content of TC, TG and PL in HL + CG group. Lipid-lowering property of the CG extract in chronic hyperlipidemic rats validates its use traditionally as a part of folklore medicine in North-eastern India, though there is no scientific evaluation to date.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalInternational Journal of Green Pharmacy
Volume3
Issue number4
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Keywords

  • Cholesterol
  • Clerodendron glandulosum. Coleb
  • Hyperlipidemia
  • Lipoproteins

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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