A prognostic score for patients with lower risk myelodysplastic syndrome

G. Garcia-Manero, J. Shan, S. Faderl, J. Cortes, F. Ravandi, G. Borthakur, W. G. Wierda, S. Pierce, E. Estey, J. Liu, X. Huang, H. Kantarjian

Research output: Contribution to journalArticle

233 Scopus citations

Abstract

Current prognostic models for myelodysplastic syndromes (MDS) do not allow the identification of patients with lower risk disease and poor prognosis that may benefit from early therapeutic intervention. We evaluated the characteristics of 856 patients with low or intermediate-1 disease by the International Prognostic Scoring System. Mean follow-up was 19.6 months (range 1-262). Of these patients, 87 (10%) transformed to acute myelogenous leukemia, and 429 (50%) had died. By multivariate analysis, characteristics associated with worse survival (P<0.01) were low platelets, anemia, older age, higher percent of marrow blasts and poor-risk cytogenetics. Although not included in the model, higher ferritin (P=0.007) and β2-microglobulin (P<0.001) levels were associated with worse prognosis. This allowed the development of a scoring system in which patients could be grouped in three categories: category 1 (n=182, 21%) with a median survival of 80.3 months (95% CI 68-NA); category 2 (n=408, 48%) with a median survival of 26.6 months (95% CI 22-32) and category 3 (n=265, 31%) with a median survival of 14.2 months (95% CI 13-18). In summary, this analysis indicates that it is possible to identify patients with lower risk MDS and poor prognosis who may benefit from early intervention.

Original languageEnglish (US)
Pages (from-to)538-543
Number of pages6
JournalLeukemia
Volume22
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'A prognostic score for patients with lower risk myelodysplastic syndrome'. Together they form a unique fingerprint.

  • Cite this

    Garcia-Manero, G., Shan, J., Faderl, S., Cortes, J., Ravandi, F., Borthakur, G., Wierda, W. G., Pierce, S., Estey, E., Liu, J., Huang, X., & Kantarjian, H. (2008). A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia, 22(3), 538-543. https://doi.org/10.1038/sj.leu.2405070