A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation

Anna Christina Dela Cruz, Valery Vilchez, Sooyeon Kim, Benjamin Barnes, Abhishek Ravinuthala, Anthony Zanni, Roberto Galuppo, Achuthan Sourianarayanane, Trushar Patel, Erin Maynard, Malay B. Shah, Michael F. Daily, Timothy Uhl, Karyn Esser, Roberto Gedaly

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods: Single-center, prospective analysis. Results: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005). Conclusions: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.

Original languageEnglish (US)
Pages (from-to)958-964
Number of pages7
JournalClinical Transplantation
Volume29
Issue number11
DOIs
StatePublished - Nov 2015
Externally publishedYes

Keywords

  • Cirrhosis
  • Grip strength
  • Liver transplantation
  • Physical activity

ASJC Scopus subject areas

  • Transplantation

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