A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality

Tomi Akinyemiju, Justin Xavier Moore, Maria Pisu, Suzanne E. Judd, Michael Goodman, James M. Shikany, Virginia J. Howard, Monika Safford, Susan C. Gilchrist

Research output: Contribution to journalArticle

Abstract

Objective: This study examined whether metabolic health status is associated with risk of cancer mortality and whether this varies by body mass index (BMI) category. Methods: A prospective study of 22,514 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was performed. Metabolically unhealthy status was defined as having three or more of the following: (1) elevated fasting glucose, (2) high triglycerides, (3) dyslipidemia, (4) hypertension, and (5) elevated waist circumference. Participants were categorized into normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2), and obesity (BMI ≥ 30 kg/m2) groups. Cox proportional hazards regression was performed to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for cancer mortality during follow-up. Results: Among participants with normal weight, participants who were metabolically unhealthy had an increased risk of cancer mortality (HR: 1.65; 95% CI: 1.20-2.26) compared with metabolically healthy participants. The overall mortality risk for participants who were metabolically unhealthy and had normal weight was stronger for obesity-related cancers (HR: 2.40; 95% CI: 1.17-4.91). Compared with participants with normal weight, those who were metabolically healthy and overweight were at a reduced risk of any cancer mortality (adjusted HR: 0.79; 95% CI: 0.63-0.99). Conclusions: There was an increased risk of overall and obesity-related cancer mortality among metabolically unhealthy participants with normal weight.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalObesity
Volume26
Issue number1
DOIs
StatePublished - Jan 2018

Fingerprint

Obesity
Prospective Studies
Mortality
Health
Weights and Measures
Body Mass Index
Confidence Intervals
Neoplasms
Waist Circumference
Dyslipidemias
Health Status
Fasting
Healthy Volunteers
Triglycerides
Stroke
Hypertension
Glucose

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Akinyemiju, T., Moore, J. X., Pisu, M., Judd, S. E., Goodman, M., Shikany, J. M., ... Gilchrist, S. C. (2018). A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. Obesity, 26(1), 193-201. https://doi.org/10.1002/oby.22067

A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. / Akinyemiju, Tomi; Moore, Justin Xavier; Pisu, Maria; Judd, Suzanne E.; Goodman, Michael; Shikany, James M.; Howard, Virginia J.; Safford, Monika; Gilchrist, Susan C.

In: Obesity, Vol. 26, No. 1, 01.2018, p. 193-201.

Research output: Contribution to journalArticle

Akinyemiju, T, Moore, JX, Pisu, M, Judd, SE, Goodman, M, Shikany, JM, Howard, VJ, Safford, M & Gilchrist, SC 2018, 'A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality', Obesity, vol. 26, no. 1, pp. 193-201. https://doi.org/10.1002/oby.22067
Akinyemiju T, Moore JX, Pisu M, Judd SE, Goodman M, Shikany JM et al. A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. Obesity. 2018 Jan;26(1):193-201. https://doi.org/10.1002/oby.22067
Akinyemiju, Tomi ; Moore, Justin Xavier ; Pisu, Maria ; Judd, Suzanne E. ; Goodman, Michael ; Shikany, James M. ; Howard, Virginia J. ; Safford, Monika ; Gilchrist, Susan C. / A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. In: Obesity. 2018 ; Vol. 26, No. 1. pp. 193-201.
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