A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis

Wen Hai Shao, Yuxuan Zhen, Joshua Rosenbaum, Robert A. Eisenberg, Tracy L. McGaha, Mark Birkenbach, Philip L. Cohen

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.

Original languageEnglish (US)
Pages (from-to)236-244
Number of pages9
JournalClinical Immunology
Volume136
Issue number2
DOIs
StatePublished - Aug 1 2010

Keywords

  • Apoptotic clearance
  • Cytokine regulation
  • Glomerulonephritis
  • MerTK

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Shao, W. H., Zhen, Y., Rosenbaum, J., Eisenberg, R. A., McGaha, T. L., Birkenbach, M., & Cohen, P. L. (2010). A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clinical Immunology, 136(2), 236-244. https://doi.org/10.1016/j.clim.2010.04.002