A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors

Zhengwen An, Maja Sabalic, Ryan Fredric Bloomquist, Teresa E. Fowler, Todd Streelman, Paul T. Sharpe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1+ MSCs decrease dramatically in number. When adult incisors are cut, the growth rate increases to rapidly re-establish tooth length and homeostasis. This accelerated growth rate correlates with the re-Appearance of CD90/Thy+ MSCs and re-establishment of their contribution to cell differentiation. A population of Celsr1+ quiescent cells becomes mitotic following clipping and replenishes the CD90/Thy1 population. A sub-population of MSCs thus exists in the mouse incisor, distinguished by expression of CD90/Thy1 that plays a specific role only during periods of increased growth rate.

Original languageEnglish (US)
Article number378
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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stem cells
Incisor
Stem cells
Mesenchymal Stromal Cells
mice
Cells
homeostasis
Growth
cells
Population
Homeostasis
progeny
teeth
markers
Cell Differentiation
Tooth

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors. / An, Zhengwen; Sabalic, Maja; Bloomquist, Ryan Fredric; Fowler, Teresa E.; Streelman, Todd; Sharpe, Paul T.

In: Nature Communications, Vol. 9, No. 1, 378, 01.12.2018.

Research output: Contribution to journalArticle

An, Zhengwen ; Sabalic, Maja ; Bloomquist, Ryan Fredric ; Fowler, Teresa E. ; Streelman, Todd ; Sharpe, Paul T. / A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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