A relationship between neonatal breast size and cord blood testosterone level

G. L. Francis, W. H. Hoffman, R. R. Gala, J. C. McPherson, Julie Kay Zadinsky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study was performed to determine if any hormone measured in cord blood correlates with the size of the neonatal breast or the presence of galactorrhea. A total of 144 term newborn infants were examined. Estradiol (E2), progesterone (P), testosterone (T), and thyrotropin (TSH) were determined by radioimmunoassay (RIA), and prolactin (PRL) was determined by both RIA and biological activity (BA). The female breast (8.5 ± 2.0 mm) was found to be larger than that of the male (7.8 ± 2.1 mm, p < 0.05). The only hormonal difference between sexes was a higher T level in the male infants (8.0 ± 3.0 nmol per L vs. 5.5 ± 1.9 nmol per L, p = 0.002). None of the other hormones measured by RIA correlated with the size of the neonatal breast or the presence of galactorrhea. The BA or PRL was widely variable compared to the PRL RIA but also failed to correlate with neonatal breast size or galactorrhea. This study suggests that T might be one factor in determining the size of neonatal breast.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalAnnals of Clinical and Laboratory Science
Volume20
Issue number4
StatePublished - Aug 3 1990
Externally publishedYes

Fingerprint

Fetal Blood
Prolactin
Testosterone
Galactorrhea
Breast
Blood
Radioimmunoassay
Bioactivity
Hormones
Thyrotropin
Progesterone
Estradiol
Sex Characteristics
Newborn Infant

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

A relationship between neonatal breast size and cord blood testosterone level. / Francis, G. L.; Hoffman, W. H.; Gala, R. R.; McPherson, J. C.; Zadinsky, Julie Kay.

In: Annals of Clinical and Laboratory Science, Vol. 20, No. 4, 03.08.1990, p. 239-244.

Research output: Contribution to journalArticle

Francis, GL, Hoffman, WH, Gala, RR, McPherson, JC & Zadinsky, JK 1990, 'A relationship between neonatal breast size and cord blood testosterone level', Annals of Clinical and Laboratory Science, vol. 20, no. 4, pp. 239-244.
Francis, G. L. ; Hoffman, W. H. ; Gala, R. R. ; McPherson, J. C. ; Zadinsky, Julie Kay. / A relationship between neonatal breast size and cord blood testosterone level. In: Annals of Clinical and Laboratory Science. 1990 ; Vol. 20, No. 4. pp. 239-244.
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