A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

J. J. Drabick, V. L. Horning, J. L. Lennox, P. E. Coyne, C. N. Oster, R. D. Knight, Thomas A Dillard, S. A. Fuller, J. J. Damato, D. S. Burke

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Abstract

Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.

Original languageEnglish (US)
Pages (from-to)93-94
Number of pages2
JournalMilitary medicine
Volume156
Issue number2
StatePublished - Jan 1 1991

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Western Blotting
HIV
HIV-1
Histiocytic Necrotizing Lymphadenitis
Histiocytic Sarcoma
Hashimoto Disease
Retroviridae
Non-Hodgkin's Lymphoma
Population
HIV Infections
Antibodies
Proteins

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Drabick, J. J., Horning, V. L., Lennox, J. L., Coyne, P. E., Oster, C. N., Knight, R. D., ... Burke, D. S. (1991). A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns. Military medicine, 156(2), 93-94.

A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns. / Drabick, J. J.; Horning, V. L.; Lennox, J. L.; Coyne, P. E.; Oster, C. N.; Knight, R. D.; Dillard, Thomas A; Fuller, S. A.; Damato, J. J.; Burke, D. S.

In: Military medicine, Vol. 156, No. 2, 01.01.1991, p. 93-94.

Research output: Contribution to journalArticle

Drabick, JJ, Horning, VL, Lennox, JL, Coyne, PE, Oster, CN, Knight, RD, Dillard, TA, Fuller, SA, Damato, JJ & Burke, DS 1991, 'A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns', Military medicine, vol. 156, no. 2, pp. 93-94.
Drabick JJ, Horning VL, Lennox JL, Coyne PE, Oster CN, Knight RD et al. A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns. Military medicine. 1991 Jan 1;156(2):93-94.
Drabick, J. J. ; Horning, V. L. ; Lennox, J. L. ; Coyne, P. E. ; Oster, C. N. ; Knight, R. D. ; Dillard, Thomas A ; Fuller, S. A. ; Damato, J. J. ; Burke, D. S. / A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns. In: Military medicine. 1991 ; Vol. 156, No. 2. pp. 93-94.
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