A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: Genetic evidence of synergism with lymphotoxin β

Pandelakis A. Koni, Richard A. Flavell

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Lymphotoxin α (LTα) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin β receptor (LTβR) as a heterotrimeric LTα1β2 complex. LTα-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTβ-deficient mice and TNFR- deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTβ and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LTβ, acting presumably via LTβR. A complete lack of only PPs in mice heterozygous for both ltα and ltβ, but not ltα or ltβ alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1(-/-) mice.

Original languageEnglish (US)
Pages (from-to)1977-1983
Number of pages7
JournalJournal of Experimental Medicine
Volume187
Issue number12
DOIs
StatePublished - Jun 15 1998

Fingerprint

Receptors, Tumor Necrosis Factor, Type I
Lymphotoxin-alpha
Lymphoid Tissue
Peyer's Patches
Tumor Necrosis Factor Receptors
Lymph Nodes
Ligands

Keywords

  • Knockout mice
  • Lymphotoxin beta
  • Mesenteric lymph nodes
  • Peyer's patches
  • Tumor necrosis factor receptor 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development : Genetic evidence of synergism with lymphotoxin β. / Koni, Pandelakis A.; Flavell, Richard A.

In: Journal of Experimental Medicine, Vol. 187, No. 12, 15.06.1998, p. 1977-1983.

Research output: Contribution to journalArticle

@article{702eec4e6b5c4a9684aac873ed5ff767,
title = "A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: Genetic evidence of synergism with lymphotoxin β",
abstract = "Lymphotoxin α (LTα) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin β receptor (LTβR) as a heterotrimeric LTα1β2 complex. LTα-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTβ-deficient mice and TNFR- deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTβ and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LTβ, acting presumably via LTβR. A complete lack of only PPs in mice heterozygous for both ltα and ltβ, but not ltα or ltβ alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1(-/-) mice.",
keywords = "Knockout mice, Lymphotoxin beta, Mesenteric lymph nodes, Peyer's patches, Tumor necrosis factor receptor 1",
author = "Koni, {Pandelakis A.} and Flavell, {Richard A.}",
year = "1998",
month = "6",
day = "15",
doi = "10.1084/jem.187.12.1977",
language = "English (US)",
volume = "187",
pages = "1977--1983",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "12",

}

TY - JOUR

T1 - A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development

T2 - Genetic evidence of synergism with lymphotoxin β

AU - Koni, Pandelakis A.

AU - Flavell, Richard A.

PY - 1998/6/15

Y1 - 1998/6/15

N2 - Lymphotoxin α (LTα) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin β receptor (LTβR) as a heterotrimeric LTα1β2 complex. LTα-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTβ-deficient mice and TNFR- deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTβ and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LTβ, acting presumably via LTβR. A complete lack of only PPs in mice heterozygous for both ltα and ltβ, but not ltα or ltβ alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1(-/-) mice.

AB - Lymphotoxin α (LTα) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin β receptor (LTβR) as a heterotrimeric LTα1β2 complex. LTα-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTβ-deficient mice and TNFR- deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTβ and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LTβ, acting presumably via LTβR. A complete lack of only PPs in mice heterozygous for both ltα and ltβ, but not ltα or ltβ alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1(-/-) mice.

KW - Knockout mice

KW - Lymphotoxin beta

KW - Mesenteric lymph nodes

KW - Peyer's patches

KW - Tumor necrosis factor receptor 1

UR - http://www.scopus.com/inward/record.url?scp=0032526543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032526543&partnerID=8YFLogxK

U2 - 10.1084/jem.187.12.1977

DO - 10.1084/jem.187.12.1977

M3 - Article

C2 - 9625757

AN - SCOPUS:0032526543

VL - 187

SP - 1977

EP - 1983

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 12

ER -