A soft-tissue coupling for wound closure

Alan J. Melvin, David B. Melvin, William J. Kitzmiller, Kyle R. Fath, Paul W. Biddinger, Natalia Juncosa-Melvin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Wounds often cannot be successfully closed by conventional means of closure such as sutures or staples. Our group developed the FiberSecureTM device to close soft tissue wounds reliably, surpassing native tissue strength. We closed cross-fiber muscle incisions, to evaluate (1) four different configurations of FiberSecureTM for 30 days, then (2) the resulting preferred configuration for 180 days. The four treatment groups each placed 21,504 polyester (PET) 12-μm fibers (cross-sectional area 1% of muscle) traversing the incision, in the form of (A) Four large (No.7 suture) non-textured bundles, (B) Eight small (No.2 suture) non-textured, (C) Four large textured, or (D) Eight small textured. Four incisions were closed in the external oblique muscle of 16 Sinclair minipigs. At 30 days, specimens were removed for biomechanics, histology, and total collagen content. Group (B) was selected for 180-day evaluations in the same wound model in eight animals, four closures each (n = 32), again with biomechanics and histology. In strength testing, every specimen tore through muscle remotely, while the repair region remained intact. Maximum forces were (A) 37.8 ± 3.9 N, (B) 37.1 ± 4.7 N, (C) 39.0 ± 5.3 N, and (D) 32.4 ± 3.4 N at 30 days, and 37.2 ± 11.3 N at 180 days (mean ± SEM). No significant difference was observed among the groups or time points (p > 0.05).

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume97 B
Issue number1
DOIs
StatePublished - Apr 1 2011

Fingerprint

Sutures
Muscle
Tissue
Biomechanical Phenomena
Muscles
Histology
Biomechanics
Wounds and Injuries
Miniature Swine
Polyesters
Fibers
Collagen
Equipment and Supplies
Animals
Repair
Scanning electron microscopy
Testing
Therapeutics
Abdominal Oblique Muscles

Keywords

  • fixation
  • muscle
  • polymer
  • suture
  • wound closure

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Melvin, A. J., Melvin, D. B., Kitzmiller, W. J., Fath, K. R., Biddinger, P. W., & Juncosa-Melvin, N. (2011). A soft-tissue coupling for wound closure. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 97 B(1), 184-189. https://doi.org/10.1002/jbm.b.31802

A soft-tissue coupling for wound closure. / Melvin, Alan J.; Melvin, David B.; Kitzmiller, William J.; Fath, Kyle R.; Biddinger, Paul W.; Juncosa-Melvin, Natalia.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 97 B, No. 1, 01.04.2011, p. 184-189.

Research output: Contribution to journalArticle

Melvin, AJ, Melvin, DB, Kitzmiller, WJ, Fath, KR, Biddinger, PW & Juncosa-Melvin, N 2011, 'A soft-tissue coupling for wound closure', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 97 B, no. 1, pp. 184-189. https://doi.org/10.1002/jbm.b.31802
Melvin, Alan J. ; Melvin, David B. ; Kitzmiller, William J. ; Fath, Kyle R. ; Biddinger, Paul W. ; Juncosa-Melvin, Natalia. / A soft-tissue coupling for wound closure. In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2011 ; Vol. 97 B, No. 1. pp. 184-189.
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