A study of recurrent stone formers with special reference to renal tubular acidosis

P P Singh, A K Pendse, A Ahmed, D V Ramavataram, Surendra Kumar Rajpurohit

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Abstract

Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by acid challenge test (150 mg ammonium chloride/kg body weight). Their 24-h urine samples were analysed for creatinine, calcium, oxalic acid, inorganic phosphorus, uric acid, magnesium and citric acid. One-hour urine samples before acid load and hourly samples for the 7 h following acid challenge test were collected and analysed for creatinine, calcium, citric acid, inorganic phosphorus, titratable acidity, and ammonium. The incidence of distal RTA defect was 22.2% in the patients examined. The major biochemical characteristics in RTA patients compared with patients without RTA were: (a) significantly higher urinary pH, (b) significantly lower excretion of citric acid, (c) no significant difference in calcium excretion and (d) a tendency toward lower titratable acidity and ammonium excretion.

Original languageEnglish (US)
Pages (from-to)201-3
Number of pages3
JournalUrological Research
Volume23
Issue number3
StatePublished - 1995

Keywords

  • Acidosis, Renal Tubular
  • Adult
  • Citrates
  • Citric Acid
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney Calculi
  • Kidney Tubules, Distal
  • Male
  • Middle Aged
  • Recurrence
  • Urine

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    Singh, P. P., Pendse, A. K., Ahmed, A., Ramavataram, D. V., & Rajpurohit, S. K. (1995). A study of recurrent stone formers with special reference to renal tubular acidosis. Urological Research, 23(3), 201-3.