Abstract
The transmission/disequilibrium (TD) test (TDT), proposed, by Spielman et al., for binary traits is a powerful method for detection of linkage between a marker locus and a disease locus, in the presence of allelic association. As a test for linkage disequilibrium, the TDT makes the assumption that any allelic association present is due to linkage. Allison proposed a series of TD-type tests for quantitative traits and calculated their power, assuming that the marker locus is the disease locus. All these tests assume that the observations are independent, and therefore they are applicable, as a test for linkage, only for nuclear-family data. In this report, we propose a regression-based TD-type test for linkage between a marker locus and a quantitative trait locus, using information on the parent- to-offspring transmission status of the associated allele at the marker locus. This method does not require independence of observations, thus allowing for analysis of pedigree data as well, and allows adjustment for covariates. We investigate the statistical power and validity of the test by simulating markers at various recombination fractions from the disease locus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 236-245 |
| Number of pages | 10 |
| Journal | American Journal of Human Genetics |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1999 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
A test of transmission/disequilibrium for quantitative trails in pedigree data, by multiple regression. / George, Varghese; Tiwari, Hemant K.; Zhu, Xiaofeng; Elston, Robert C.
In: American Journal of Human Genetics, Vol. 65, No. 1, 01.01.1999, p. 236-245.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A test of transmission/disequilibrium for quantitative trails in pedigree data, by multiple regression
AU - George, Varghese
AU - Tiwari, Hemant K.
AU - Zhu, Xiaofeng
AU - Elston, Robert C.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The transmission/disequilibrium (TD) test (TDT), proposed, by Spielman et al., for binary traits is a powerful method for detection of linkage between a marker locus and a disease locus, in the presence of allelic association. As a test for linkage disequilibrium, the TDT makes the assumption that any allelic association present is due to linkage. Allison proposed a series of TD-type tests for quantitative traits and calculated their power, assuming that the marker locus is the disease locus. All these tests assume that the observations are independent, and therefore they are applicable, as a test for linkage, only for nuclear-family data. In this report, we propose a regression-based TD-type test for linkage between a marker locus and a quantitative trait locus, using information on the parent- to-offspring transmission status of the associated allele at the marker locus. This method does not require independence of observations, thus allowing for analysis of pedigree data as well, and allows adjustment for covariates. We investigate the statistical power and validity of the test by simulating markers at various recombination fractions from the disease locus.
AB - The transmission/disequilibrium (TD) test (TDT), proposed, by Spielman et al., for binary traits is a powerful method for detection of linkage between a marker locus and a disease locus, in the presence of allelic association. As a test for linkage disequilibrium, the TDT makes the assumption that any allelic association present is due to linkage. Allison proposed a series of TD-type tests for quantitative traits and calculated their power, assuming that the marker locus is the disease locus. All these tests assume that the observations are independent, and therefore they are applicable, as a test for linkage, only for nuclear-family data. In this report, we propose a regression-based TD-type test for linkage between a marker locus and a quantitative trait locus, using information on the parent- to-offspring transmission status of the associated allele at the marker locus. This method does not require independence of observations, thus allowing for analysis of pedigree data as well, and allows adjustment for covariates. We investigate the statistical power and validity of the test by simulating markers at various recombination fractions from the disease locus.
UR - http://www.scopus.com/inward/record.url?scp=0033364734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033364734&partnerID=8YFLogxK
U2 - 10.1086/302444
DO - 10.1086/302444
M3 - Article
C2 - 10364537
AN - SCOPUS:0033364734
VL - 65
SP - 236
EP - 245
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 1
ER -