A theoretical model for oxygen transport in skeletal muscle under conditions of high oxygen demand

Brooke J McGuire, T. W. Secomb

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Oxygen transport from capillaries to exercising skeletal muscle is studied by use of a Krogh-type cylinder model. The goal is to predict oxygen consumption under conditions of high demand, on the basis of a consideration of transport processes occurring at the microvascular level. Effects of the decline in oxygen content of blood flowing along capillaries, intravascular resistance to oxygen diffusion, and myoglobin-facilitated diffusion are included. Parameter values are based on human skeletal muscle. The dependence of oxygen consumption on oxygen demand, perfusion, and capillary density are examined. When demand is moderate, the tissue is well oxygenated and consumption is slightly less than demand. When demand is high, capillary oxygen content declines rapidly with axial distance and radial oxygen transport is limited by diffusion resistance within the capillary and the tissue. Under these conditions, much of the tissue is hypoxic, consumption is substantially less than demand, and consumption is strongly dependent on capillary density. Predicted consumption rates are comparable with experimentally observed maximal rates of oxygen consumption.

Original languageEnglish (US)
Pages (from-to)2255-2265
Number of pages11
JournalJournal of Applied Physiology
Volume91
Issue number5
StatePublished - Nov 10 2001
Externally publishedYes

Fingerprint

Skeletal Muscle
Theoretical Models
Oxygen
Capillary Resistance
Oxygen Consumption
Facilitated Diffusion
Myoglobin
Perfusion

Keywords

  • Krogh cylinder model
  • Maximal oxygen consumption
  • Oxygen diffusion

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

A theoretical model for oxygen transport in skeletal muscle under conditions of high oxygen demand. / McGuire, Brooke J; Secomb, T. W.

In: Journal of Applied Physiology, Vol. 91, No. 5, 10.11.2001, p. 2255-2265.

Research output: Contribution to journalArticle

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