A three-dimensional morphometric study of craniofacial shape in schizophrenia

Peter F. Buckley, David Dean, Fred L. Bookstein, Seungho Han, Michael Yerukhimovich, Kyoung June Min, Beth Singer

Research output: Contribution to journalArticle

38 Scopus citations


Background: Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. Method: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. Results: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. Conclusions: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number3
StatePublished - Mar 1 2005

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Buckley, P. F., Dean, D., Bookstein, F. L., Han, S., Yerukhimovich, M., Min, K. J., & Singer, B. (2005). A three-dimensional morphometric study of craniofacial shape in schizophrenia. American Journal of Psychiatry, 162(3), 606-608. https://doi.org/10.1176/appi.ajp.162.3.606