A transcription map of the major histocompatibility complex (MHC) class I region

J. R. Gruen, S. R. Nalabolu, T. W. Chu, C. Bowlus, W. F. Fan, Vita Lan-Ing Goei, H. Wei, R. Sivakamasundari, Y. C. Liu, H. X. Xu, S. Parimoo, G. Nallur, R. Ajioka, H. Shukla, P. Bray-Ward, J. Pan, S. M. Weissman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.

Original languageEnglish (US)
Pages (from-to)70-85
Number of pages16
JournalGenomics
Volume36
Issue number1
DOIs
StatePublished - Aug 15 1996
Externally publishedYes

Fingerprint

Major Histocompatibility Complex
Genes
MHC Class I Genes
Pseudogenes
HLA-A Antigens
Expressed Sequence Tags
Zinc Fingers
Histones
Immune System
Complementary DNA
DNA
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Gruen, J. R., Nalabolu, S. R., Chu, T. W., Bowlus, C., Fan, W. F., Goei, V. L-I., ... Weissman, S. M. (1996). A transcription map of the major histocompatibility complex (MHC) class I region. Genomics, 36(1), 70-85. https://doi.org/10.1006/geno.1996.0427

A transcription map of the major histocompatibility complex (MHC) class I region. / Gruen, J. R.; Nalabolu, S. R.; Chu, T. W.; Bowlus, C.; Fan, W. F.; Goei, Vita Lan-Ing; Wei, H.; Sivakamasundari, R.; Liu, Y. C.; Xu, H. X.; Parimoo, S.; Nallur, G.; Ajioka, R.; Shukla, H.; Bray-Ward, P.; Pan, J.; Weissman, S. M.

In: Genomics, Vol. 36, No. 1, 15.08.1996, p. 70-85.

Research output: Contribution to journalArticle

Gruen, JR, Nalabolu, SR, Chu, TW, Bowlus, C, Fan, WF, Goei, VL-I, Wei, H, Sivakamasundari, R, Liu, YC, Xu, HX, Parimoo, S, Nallur, G, Ajioka, R, Shukla, H, Bray-Ward, P, Pan, J & Weissman, SM 1996, 'A transcription map of the major histocompatibility complex (MHC) class I region', Genomics, vol. 36, no. 1, pp. 70-85. https://doi.org/10.1006/geno.1996.0427
Gruen, J. R. ; Nalabolu, S. R. ; Chu, T. W. ; Bowlus, C. ; Fan, W. F. ; Goei, Vita Lan-Ing ; Wei, H. ; Sivakamasundari, R. ; Liu, Y. C. ; Xu, H. X. ; Parimoo, S. ; Nallur, G. ; Ajioka, R. ; Shukla, H. ; Bray-Ward, P. ; Pan, J. ; Weissman, S. M. / A transcription map of the major histocompatibility complex (MHC) class I region. In: Genomics. 1996 ; Vol. 36, No. 1. pp. 70-85.
@article{3d6ff754680a49d4a72e6abe8e1cff08,
title = "A transcription map of the major histocompatibility complex (MHC) class I region",
abstract = "We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.",
author = "Gruen, {J. R.} and Nalabolu, {S. R.} and Chu, {T. W.} and C. Bowlus and Fan, {W. F.} and Goei, {Vita Lan-Ing} and H. Wei and R. Sivakamasundari and Liu, {Y. C.} and Xu, {H. X.} and S. Parimoo and G. Nallur and R. Ajioka and H. Shukla and P. Bray-Ward and J. Pan and Weissman, {S. M.}",
year = "1996",
month = "8",
day = "15",
doi = "10.1006/geno.1996.0427",
language = "English (US)",
volume = "36",
pages = "70--85",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - A transcription map of the major histocompatibility complex (MHC) class I region

AU - Gruen, J. R.

AU - Nalabolu, S. R.

AU - Chu, T. W.

AU - Bowlus, C.

AU - Fan, W. F.

AU - Goei, Vita Lan-Ing

AU - Wei, H.

AU - Sivakamasundari, R.

AU - Liu, Y. C.

AU - Xu, H. X.

AU - Parimoo, S.

AU - Nallur, G.

AU - Ajioka, R.

AU - Shukla, H.

AU - Bray-Ward, P.

AU - Pan, J.

AU - Weissman, S. M.

PY - 1996/8/15

Y1 - 1996/8/15

N2 - We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.

AB - We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.

UR - http://www.scopus.com/inward/record.url?scp=0030586949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030586949&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0427

DO - 10.1006/geno.1996.0427

M3 - Article

VL - 36

SP - 70

EP - 85

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 1

ER -