A unique “Angiotensin-Sensitive” neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress

Annette D. de Kloet, Lei Wang, Soledad Pitra, Helmut Hiller, Justin A. Smith, Yalun Tan, Dani Nguyen, Karlena M. Cahill, Colin Sumners, Javier Eduardo Stern, Eric G. Krause

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Stress elicits neuroendocrine, autonomic, and behavioral responses that mitigate homeostatic imbalance and ensure survival. However, chronic engagement of such responses promotes psychological, cardiovascular, and metabolic impairments. In recent years, the renin-angiotensin system has emerged as a key mediator of stress responding and its related pathologies, but the neuronal circuits that orchestrate these interactions are not known. These studies combine the use of the Cre-recombinase/loxP system in mice with optogenetics to structurally and functionally characterize angiotensin type-1a receptor-containing neurons of the paraventricular nucleus of the hypothalamus, the goal being to determine the extent of their involvement in the regulation of stress responses. Initial studies use neuroanatomical techniques to reveal that angiotensin type-1a receptors are localized predominantly to the parvocellular neurosecretory neurons of the paraventricular nucleus of the hypothalamus. These neurons are almost exclusively glutamatergic and send dense projections totheexterior portionof themedianeminence. Furthermore, theseneurons largelyexpress corticotrophin-releasinghormoneor thyrotropin-releasing hormone and do not express arginine vasopressin or oxytocin. Functionally, optogenetic stimulation of these neurons promotes the activation of the hypothalamic-pituitary–adrenal and hypothalamic-pituitary–thyroid axes, as well as a rise in systolic blood pressure. When these neurons are optogenetically inhibited, the activity of these neuroendocrine axes are suppressed and anxiety-like behavior in the elevated plus maze is dampened. Collectively, these studies implicate this neuronal population in the integration and coordination of the physiological responses to stress and may therefore serve as a potential target for therapeutic intervention for stress-related pathology.

Original languageEnglish (US)
Pages (from-to)3478-3490
Number of pages13
JournalJournal of Neuroscience
Volume37
Issue number13
DOIs
StatePublished - Mar 29 2017

Fingerprint

Angiotensins
Vulnerable Populations
Neurons
Optogenetics
Angiotensin Type 1 Receptor
Paraventricular Hypothalamic Nucleus
Hypothalamus
Pathology
Vasotocin
Blood Pressure
Physiological Stress
Thyrotropin-Releasing Hormone
Arginine Vasopressin
Renin-Angiotensin System
Adrenocorticotropic Hormone
Anxiety
Psychology
Survival
Population

Keywords

  • Anxiety
  • Cardiovascular
  • Depression
  • Glucocorticoids
  • Hypertension
  • Thyroid

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A unique “Angiotensin-Sensitive” neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress. / de Kloet, Annette D.; Wang, Lei; Pitra, Soledad; Hiller, Helmut; Smith, Justin A.; Tan, Yalun; Nguyen, Dani; Cahill, Karlena M.; Sumners, Colin; Stern, Javier Eduardo; Krause, Eric G.

In: Journal of Neuroscience, Vol. 37, No. 13, 29.03.2017, p. 3478-3490.

Research output: Contribution to journalArticle

de Kloet, AD, Wang, L, Pitra, S, Hiller, H, Smith, JA, Tan, Y, Nguyen, D, Cahill, KM, Sumners, C, Stern, JE & Krause, EG 2017, 'A unique “Angiotensin-Sensitive” neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress', Journal of Neuroscience, vol. 37, no. 13, pp. 3478-3490. https://doi.org/10.1523/JNEUROSCI.3674-16.2017
de Kloet, Annette D. ; Wang, Lei ; Pitra, Soledad ; Hiller, Helmut ; Smith, Justin A. ; Tan, Yalun ; Nguyen, Dani ; Cahill, Karlena M. ; Sumners, Colin ; Stern, Javier Eduardo ; Krause, Eric G. / A unique “Angiotensin-Sensitive” neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 13. pp. 3478-3490.
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AU - Smith, Justin A.

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AU - Nguyen, Dani

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