A volumetric study of CyberKnife hypofractionated stereotactic radiotherapy as salvage for progressive malignant brain tumors

Initial experience

Cole A. Giller, Brian D. Berger, Karen Fink, Eleanor Bastian

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Radiosurgery is frequently offered to patients with progressive malignant brain tumors if radiation therapy or chemotherapy fails to provide local control. The use of single-shot regimens, however, is limited by the risk of complications when the tumor is large, surrounded by edema or has been pre-treated with radiation. Hypofractionation may confer safety but has not been tested for these difficult tumors. We report the results of hypofractionation as an alternative option in a small cohort of progressive malignant brain tumors. Methods: Hypofractionated CyberKnife radiotherapy was chosen for 18 progressive malignant brain tumors (six high-grade gliomas and 12 metastatic lesions) in 15 patients because of size, previous treatment witn radiation or surrounding edema. The mean dose was 21 ± 4 Gy and the number of fractions was 5 ± 0.6. The volume of each tumor at treatment was compared with the volume at follow-up. Results: Thirteen of the 18 tumors (72%) showed a volume decrease. The average volume change was a decrease of 16 ± 58% (median: 20%) with a follow-up of 180 ± 121 days (median: 172 days). Toxicity occurred in only one patient, with symptoms improving on steroids. Discussion: Progression of malignant brain tumors not ideal for single-shot radiosurgery can be arrested or reversed, at least for short periods, with minimal toxicity using hypofractionated radiotherapy. Longer studies will be needed to assess durability of this response in these difficult tumors.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalNeurological Research
Volume29
Issue number6
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Fingerprint

Brain Neoplasms
Radiotherapy
Radiosurgery
Edema
Neoplasms
Radiation
Tumor Burden
Glioma
Steroids
Safety
Drug Therapy
Therapeutics

Keywords

  • Brain tumors
  • Cyberknife
  • Hypofractionated
  • Radiation therapy
  • Radiosurgery
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

A volumetric study of CyberKnife hypofractionated stereotactic radiotherapy as salvage for progressive malignant brain tumors : Initial experience. / Giller, Cole A.; Berger, Brian D.; Fink, Karen; Bastian, Eleanor.

In: Neurological Research, Vol. 29, No. 6, 01.09.2007, p. 563-568.

Research output: Contribution to journalArticle

Giller, Cole A. ; Berger, Brian D. ; Fink, Karen ; Bastian, Eleanor. / A volumetric study of CyberKnife hypofractionated stereotactic radiotherapy as salvage for progressive malignant brain tumors : Initial experience. In: Neurological Research. 2007 ; Vol. 29, No. 6. pp. 563-568.
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