A20 Controls Macrophage to Elicit Potent Cytotoxic CD4+ T Cell Response

Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si Yi Chen, Xue F. Huang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Emerging evidence indicates that CD4+ T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4+ T cell-triggered cell killing. However, the critical issue is how the cytotoxic CD4+ T cells are developed. During the course of our work that aims at promoting immunostimulation of APCs by inhibition of negative regulators, we found that A20-silenced Mf{cyrillic} drastically induced granzyme B expression in CD4+ T cells. As a consequence, the granzyme-highly expressing CD4+ T cells exhibited a strong cytotoxic activity that restricted tumor development. We found that A20-silenced Mf{cyrillic} activated cytotoxic CD4+ T cells by MHC class-II restricted mechanism and the activation was largely dependent on enhanced production of IFN-γ.

Original languageEnglish (US)
Article numbere48930
JournalPloS one
Issue number11
StatePublished - Nov 7 2012
Externally publishedYes

ASJC Scopus subject areas

  • General


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