TY - JOUR
T1 - Abdominal Wall Hernia Repair
T2 - A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model
AU - Judge, Timothy W.
AU - Parker, David M.
AU - Dinsmore, Robert C.
N1 - Funding Information:
Funding for this study was provided by the Department of Clinical Investigations, under DDEAMC#03-38a. This article represents the personal viewpoint of the authors and cannot be construed as a statement of official Department of Defense policy. Use of commercial products in this project does not imply endorsement by the US government.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - Background: This study compared Parietex composite mesh (PCM) with Sepramesh (SM) in terms of strength of tissue incorporation, adhesion formation, and mesh shrinkage, using an animal model. Study design: A two-phase, prospective, randomized study using 44 New Zealand white rabbits. Each animal underwent creation of a standardized ventral hernia defect, followed by repair using either SM or PCM. Half of each group was sacrificed and examined at 1 month, and the remainder at 5 months. Outcomes measurements were strength of incorporation (SOI), type and area of adhesions (AA), and mesh shrinkage. Results: SOI for PCM was much greater than for SM, both at 1 month (60.8 N versus 42.6 N) and 5 months (70.9 N versus 31.5 N). The incidence of bowel adhesions was lower with PCM than SM, both at 1 month (1 versus 6) and at 5 months (0 versus 4). At 5 months, PCM demonstrated lower AA, both as a percentage of the mesh (5.6% versus 12.8%) and in terms of absolute area involved (321 mm2 versus 840 mm2). PCM underwent considerably more shrinkage than SM, at both 1 month (38.2% versus 18.1%) and 5 months (17.4% versus 6.1%). Conclusions: PCM demonstrated a substantially stronger SOI, which improved over time, and SOI of SM decreased. PCM was also superior in terms of adhesion prevention, but underwent considerably more shrinkage in this experimental model.
AB - Background: This study compared Parietex composite mesh (PCM) with Sepramesh (SM) in terms of strength of tissue incorporation, adhesion formation, and mesh shrinkage, using an animal model. Study design: A two-phase, prospective, randomized study using 44 New Zealand white rabbits. Each animal underwent creation of a standardized ventral hernia defect, followed by repair using either SM or PCM. Half of each group was sacrificed and examined at 1 month, and the remainder at 5 months. Outcomes measurements were strength of incorporation (SOI), type and area of adhesions (AA), and mesh shrinkage. Results: SOI for PCM was much greater than for SM, both at 1 month (60.8 N versus 42.6 N) and 5 months (70.9 N versus 31.5 N). The incidence of bowel adhesions was lower with PCM than SM, both at 1 month (1 versus 6) and at 5 months (0 versus 4). At 5 months, PCM demonstrated lower AA, both as a percentage of the mesh (5.6% versus 12.8%) and in terms of absolute area involved (321 mm2 versus 840 mm2). PCM underwent considerably more shrinkage than SM, at both 1 month (38.2% versus 18.1%) and 5 months (17.4% versus 6.1%). Conclusions: PCM demonstrated a substantially stronger SOI, which improved over time, and SOI of SM decreased. PCM was also superior in terms of adhesion prevention, but underwent considerably more shrinkage in this experimental model.
UR - http://www.scopus.com/inward/record.url?scp=33846269007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846269007&partnerID=8YFLogxK
U2 - 10.1016/j.jamcollsurg.2006.11.003
DO - 10.1016/j.jamcollsurg.2006.11.003
M3 - Article
C2 - 17254931
AN - SCOPUS:33846269007
SN - 1072-7515
VL - 204
SP - 276
EP - 281
JO - Surgery Gynecology and Obstetrics
JF - Surgery Gynecology and Obstetrics
IS - 2
ER -