Abdominal Wall Hernia Repair

A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model

Timothy W. Judge, David M. Parker, Robert Charles Dinsmore

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: This study compared Parietex composite mesh (PCM) with Sepramesh (SM) in terms of strength of tissue incorporation, adhesion formation, and mesh shrinkage, using an animal model. Study design: A two-phase, prospective, randomized study using 44 New Zealand white rabbits. Each animal underwent creation of a standardized ventral hernia defect, followed by repair using either SM or PCM. Half of each group was sacrificed and examined at 1 month, and the remainder at 5 months. Outcomes measurements were strength of incorporation (SOI), type and area of adhesions (AA), and mesh shrinkage. Results: SOI for PCM was much greater than for SM, both at 1 month (60.8 N versus 42.6 N) and 5 months (70.9 N versus 31.5 N). The incidence of bowel adhesions was lower with PCM than SM, both at 1 month (1 versus 6) and at 5 months (0 versus 4). At 5 months, PCM demonstrated lower AA, both as a percentage of the mesh (5.6% versus 12.8%) and in terms of absolute area involved (321 mm2 versus 840 mm2). PCM underwent considerably more shrinkage than SM, at both 1 month (38.2% versus 18.1%) and 5 months (17.4% versus 6.1%). Conclusions: PCM demonstrated a substantially stronger SOI, which improved over time, and SOI of SM decreased. PCM was also superior in terms of adhesion prevention, but underwent considerably more shrinkage in this experimental model.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalJournal of the American College of Surgeons
Volume204
Issue number2
DOIs
StatePublished - Feb 1 2007

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Abdominal Hernia
Herniorrhaphy
Abdominal Wall
Hernia
Rabbits
Tissue Adhesions
Ventral Hernia
parietex
sepramesh
Theoretical Models
Animal Models
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Abdominal Wall Hernia Repair : A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model. / Judge, Timothy W.; Parker, David M.; Dinsmore, Robert Charles.

In: Journal of the American College of Surgeons, Vol. 204, No. 2, 01.02.2007, p. 276-281.

Research output: Contribution to journalArticle

Judge, Timothy W. ; Parker, David M. ; Dinsmore, Robert Charles. / Abdominal Wall Hernia Repair : A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model. In: Journal of the American College of Surgeons. 2007 ; Vol. 204, No. 2. pp. 276-281.
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abstract = "Background: This study compared Parietex composite mesh (PCM) with Sepramesh (SM) in terms of strength of tissue incorporation, adhesion formation, and mesh shrinkage, using an animal model. Study design: A two-phase, prospective, randomized study using 44 New Zealand white rabbits. Each animal underwent creation of a standardized ventral hernia defect, followed by repair using either SM or PCM. Half of each group was sacrificed and examined at 1 month, and the remainder at 5 months. Outcomes measurements were strength of incorporation (SOI), type and area of adhesions (AA), and mesh shrinkage. Results: SOI for PCM was much greater than for SM, both at 1 month (60.8 N versus 42.6 N) and 5 months (70.9 N versus 31.5 N). The incidence of bowel adhesions was lower with PCM than SM, both at 1 month (1 versus 6) and at 5 months (0 versus 4). At 5 months, PCM demonstrated lower AA, both as a percentage of the mesh (5.6{\%} versus 12.8{\%}) and in terms of absolute area involved (321 mm2 versus 840 mm2). PCM underwent considerably more shrinkage than SM, at both 1 month (38.2{\%} versus 18.1{\%}) and 5 months (17.4{\%} versus 6.1{\%}). Conclusions: PCM demonstrated a substantially stronger SOI, which improved over time, and SOI of SM decreased. PCM was also superior in terms of adhesion prevention, but underwent considerably more shrinkage in this experimental model.",
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