Abdominal wall repair using human acellular dermis

Charles F. Bellows, Daniel Albo, David H. Berger, Samir S. Awad

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: The surgical repair of abdominal wall defects that cannot be closed primarily in contaminated fields is a difficult problem. The use of nonabsorbable synthetic materials usually is contraindicated in this setting because of the risk for colonization and chronic infection of the mesh. In this study we sought to determine the safety and efficacy of implanted human acellular dermal graft for abdominal wall reconstruction. Methods: The records of all patients (n = 20) who underwent a repair of an abdominal wall defect with human acellular dermal graft at a Veteran Affairs hospital were reviewed retrospectively. Patient demographics, complications, and hernia recurrence were recorded. Results: There were 15 perioperative complications in 11 patients: 6 graft dehiscences, 1 evisceration, 2 postoperative intra-abdominal bleeds, 5 bacterial graft infections, and 1 death. Patients with heart disease, American Society of Anesthesiologists classification of 4, and/or dirty wounds were more likely to have perioperative complications. The median follow-up period was 9.4 months (range, 2-16 mo), during which 6 hernia recurrences were noted. Conclusions: Human acellular dermis use is safe in abdominal wall reconstructions in contaminated surgical wounds.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalAmerican Journal of Surgery
Volume194
Issue number2
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Acellular Dermis
Abdominal Wall
Transplants
Hernia
Veterans Hospitals
Recurrence
Skin
Bacterial Infections
Heart Diseases
Demography
Safety
Wounds and Injuries
Infection

Keywords

  • Abdominal wall reconstruction
  • Biologic tissue graft
  • Human acellular dermis

ASJC Scopus subject areas

  • Surgery

Cite this

Abdominal wall repair using human acellular dermis. / Bellows, Charles F.; Albo, Daniel; Berger, David H.; Awad, Samir S.

In: American Journal of Surgery, Vol. 194, No. 2, 01.08.2007, p. 192-198.

Research output: Contribution to journalArticle

Bellows, Charles F. ; Albo, Daniel ; Berger, David H. ; Awad, Samir S. / Abdominal wall repair using human acellular dermis. In: American Journal of Surgery. 2007 ; Vol. 194, No. 2. pp. 192-198.
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