Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging

Interpretation in relation to the neurodevelopmental hypothesis

E. O'Callaghan, P. Buckley, O. Redmond, J. Stack, J. T. Ennis, C. Larkin, J. L. Waddington

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The nature of abnormalities of cerebral structure evident in schizophrenia on magnetic resonance imaging is considered in relation to the neurodevelopmental hypothesis of the disorder. While schizophrenic patients showed increased ventricular volume, the extent of increase with age was comparable with that evident in controls and was unrelated to duration of illness. Conversely, cortical atrophy was evident only in patients, and this increased markedly with age and duration of illness. Such findings could be suggestive of two distinct pathophysiological processes in schizophrenia, but a schema for their reconciliation with the neurodevelopmental hypothesis is elaborated.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalJournal of the Royal Society of Medicine
Volume85
Issue number4
StatePublished - Jan 1 1992

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Schizophrenia
Magnetic Resonance Imaging
Atrophy
Neurodevelopmental Disorders

ASJC Scopus subject areas

  • Medicine(all)

Cite this

O'Callaghan, E., Buckley, P., Redmond, O., Stack, J., Ennis, J. T., Larkin, C., & Waddington, J. L. (1992). Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging: Interpretation in relation to the neurodevelopmental hypothesis. Journal of the Royal Society of Medicine, 85(4), 227-231.

Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging : Interpretation in relation to the neurodevelopmental hypothesis. / O'Callaghan, E.; Buckley, P.; Redmond, O.; Stack, J.; Ennis, J. T.; Larkin, C.; Waddington, J. L.

In: Journal of the Royal Society of Medicine, Vol. 85, No. 4, 01.01.1992, p. 227-231.

Research output: Contribution to journalArticle

O'Callaghan, E, Buckley, P, Redmond, O, Stack, J, Ennis, JT, Larkin, C & Waddington, JL 1992, 'Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging: Interpretation in relation to the neurodevelopmental hypothesis', Journal of the Royal Society of Medicine, vol. 85, no. 4, pp. 227-231.
O'Callaghan, E. ; Buckley, P. ; Redmond, O. ; Stack, J. ; Ennis, J. T. ; Larkin, C. ; Waddington, J. L. / Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging : Interpretation in relation to the neurodevelopmental hypothesis. In: Journal of the Royal Society of Medicine. 1992 ; Vol. 85, No. 4. pp. 227-231.
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