ACTH protects against glucocorticoid-induced osteonecrosis of bone

Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li Liu, Yujuan Wang, Ling Ling Zhu, Xuan Liu, Jianhua Li, Yuanzhen Peng, Guozhe Yang, Xing Ming Shi, Alice Levine, Jameel Iqbal, Beatrice B. Yaroslavskiy, Carlos M Isales, Harry C. Blair

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

Original languageEnglish (US)
Pages (from-to)8782-8787
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number19
DOIs
StatePublished - May 11 2010

Keywords

  • Osteoblast
  • Osteoclast
  • Osteoporosis

ASJC Scopus subject areas

  • General

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  • Cite this

    Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M., & Blair, H. C. (2010). ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8782-8787. https://doi.org/10.1073/pnas.0912176107