ACTH protects against glucocorticoid-induced osteonecrosis of bone

Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li Liu, Yujuan Wang, Ling Ling Zhu, Xuan Liu, Jianhua Li, Yuanzhen Peng, Guozhe Yang, Xing Ming Shi, Alice Levine, Jameel Iqbal, Beatrice B. Yaroslavskiy, Carlos M Isales, Harry C. Blair

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

Original languageEnglish (US)
Pages (from-to)8782-8787
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number19
DOIs
StatePublished - May 11 2010

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Osteonecrosis
Adrenocorticotropic Hormone
Glucocorticoids
Bone and Bones
Bone Remodeling
Thigh
Vascular Endothelial Growth Factor A
Blood Vessels
Therapeutics

Keywords

  • Osteoblast
  • Osteoclast
  • Osteoporosis

ASJC Scopus subject areas

  • General

Cite this

ACTH protects against glucocorticoid-induced osteonecrosis of bone. / Zaidi, Mone; Sun, Li; Robinson, Lisa J.; Tourkova, Irina L.; Liu, Li; Wang, Yujuan; Zhu, Ling Ling; Liu, Xuan; Li, Jianhua; Peng, Yuanzhen; Yang, Guozhe; Shi, Xing Ming; Levine, Alice; Iqbal, Jameel; Yaroslavskiy, Beatrice B.; Isales, Carlos M; Blair, Harry C.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 19, 11.05.2010, p. 8782-8787.

Research output: Contribution to journalArticle

Zaidi, M, Sun, L, Robinson, LJ, Tourkova, IL, Liu, L, Wang, Y, Zhu, LL, Liu, X, Li, J, Peng, Y, Yang, G, Shi, XM, Levine, A, Iqbal, J, Yaroslavskiy, BB, Isales, CM & Blair, HC 2010, 'ACTH protects against glucocorticoid-induced osteonecrosis of bone', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 19, pp. 8782-8787. https://doi.org/10.1073/pnas.0912176107
Zaidi, Mone ; Sun, Li ; Robinson, Lisa J. ; Tourkova, Irina L. ; Liu, Li ; Wang, Yujuan ; Zhu, Ling Ling ; Liu, Xuan ; Li, Jianhua ; Peng, Yuanzhen ; Yang, Guozhe ; Shi, Xing Ming ; Levine, Alice ; Iqbal, Jameel ; Yaroslavskiy, Beatrice B. ; Isales, Carlos M ; Blair, Harry C. / ACTH protects against glucocorticoid-induced osteonecrosis of bone. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 19. pp. 8782-8787.
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AU - Levine, Alice

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