Actions of steroids in mitochondria

Larisa P Gavrilova-Jordan, Thomas M. Price

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Investigations of indirect and direct actions of steroids on the mitochondria are relatively new areas of research. In this review we provide brief background information regarding mitochondrial structure and function and then focus upon interactions of glucocorticoid, estrogen, androgen, and progesterone receptors with mitochondria. We evaluate the current evidence for steroid receptor localization in the mitochondria based on techniques of Western blot analysis, immunocytochemistry, electron microscopy, and mass spectrometry. Steroid receptor-dependent interactions with mitochondria may include transcriptional regulation of nuclear DNA-encoded mitochondrial proteins, transcriptional regulation of mitochondrial DNA-encoded proteins, or indirect effects on mitochondria due to interactions with cytoplasmic signaling peptides and non-genomic control of cation fluxes. These interactions may play a role in mitochondrial-dependent processes of oxidative phosphorylation and apoptosis. Physiological examples of these interactions are discussed.

Original languageEnglish (US)
Pages (from-to)154-164
Number of pages11
JournalSeminars in Reproductive Medicine
Volume25
Issue number3
DOIs
StatePublished - May 1 2007

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Mitochondria
Steroids
Steroid Receptors
Mitochondrial Proteins
Oxidative Phosphorylation
Glucocorticoid Receptors
Androgen Receptors
Progesterone Receptors
Mitochondrial DNA
Estrogen Receptors
Cations
Mass Spectrometry
Electron Microscopy
Western Blotting
Immunohistochemistry
Apoptosis
Peptides
DNA
Research
Proteins

Keywords

  • Apoptosis
  • Mitochondria
  • Non-genomic
  • Oxidative phosphorylation
  • Steroid receptor
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

Cite this

Actions of steroids in mitochondria. / Gavrilova-Jordan, Larisa P; Price, Thomas M.

In: Seminars in Reproductive Medicine, Vol. 25, No. 3, 01.05.2007, p. 154-164.

Research output: Contribution to journalReview article

Gavrilova-Jordan, Larisa P ; Price, Thomas M. / Actions of steroids in mitochondria. In: Seminars in Reproductive Medicine. 2007 ; Vol. 25, No. 3. pp. 154-164.
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