Acute and chronic regulation of aldosterone production

Namita G. Hattangady, Lawrence O. Olala, Wendy B Bollag, William E. Rainey

Research output: Contribution to journalReview article

146 Citations (Scopus)

Abstract

Aldosterone is the major mineralocorticoid synthesized by the adrenal and plays an important role in the regulation of systemic blood pressure through the absorption of sodium and water. Aldosterone production is regulated tightly by selective expression of aldosterone synthase (CYP11B2) in the adrenal outermost zone, the zona glomerulosa. Angiotensin II (Ang II), potassium (K +) and adrenocorticotropin (ACTH) are the main physiological agonists which regulate aldosterone secretion. Aldosterone production is regulated within minutes of stimulation (acutely) through increased expression and phosphorylation of the steroidogenic acute regulatory (StAR) protein and over hours to days (chronically) by increased expression of the enzymes involved in the synthesis of aldosterone, particularly CYP11B2. Imbalance in any of these processes may lead to several disorders of aldosterone excess. In this review we attempt to summarize the key molecular events involved in the acute and chronic phases of aldosterone secretion.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalMolecular and Cellular Endocrinology
Volume350
Issue number2
DOIs
StatePublished - Mar 24 2012

Fingerprint

Aldosterone
Cytochrome P-450 CYP11B2
Adrenocorticotropic Hormone
Zona Glomerulosa
Mineralocorticoids
Phosphorylation
Blood pressure
Angiotensin II
Potassium
Sodium
Blood Pressure
Water
Enzymes

Keywords

  • Adrenocorticotropin
  • Aldosterone synthase
  • Angiotensin II
  • Potassium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Acute and chronic regulation of aldosterone production. / Hattangady, Namita G.; Olala, Lawrence O.; Bollag, Wendy B; Rainey, William E.

In: Molecular and Cellular Endocrinology, Vol. 350, No. 2, 24.03.2012, p. 151-162.

Research output: Contribution to journalReview article

Hattangady, Namita G. ; Olala, Lawrence O. ; Bollag, Wendy B ; Rainey, William E. / Acute and chronic regulation of aldosterone production. In: Molecular and Cellular Endocrinology. 2012 ; Vol. 350, No. 2. pp. 151-162.
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