@article{1a8fcee8746941dcb8dc7f3e5b046197,
title = "Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation",
abstract = "Little is known about MYC dysregulation in myeloid malignancies, and the authors were unable to find published studies that evaluated MYC protein expression in primary cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Herein, we describe the clinical, morphologic, immunophenotypic, cytogenetic, and molecular genetic findings in two MDS/AML cases that contained both MYC rearrangement and the JAK2 V617F mutation. We also demonstrate MYC protein expression by immunohistochemistry in both patients.",
keywords = "Acute myeloid leukemia, Blastic plasmacytoid dendritic cell neoplasm, JAK2 V617F mutation, MYC",
author = "Maro Ohanian and Carlos Bueso-Ramos and Ok, {Chi Young} and Pei Lin and Keyur Patel and Alattar, {Mona Lisa} and Khoury, {Joseph D.} and Uri Rozovski and Zeev Estrov and Huh, {Yang O.} and Jorge Cortes and Abruzzo, {Lynne V.}",
note = "Funding Information: The authors thank the Clinical Cytogenetics Laboratory at The University of Texas MD Anderson Cancer Center for assistance in providing the cytogenetics images. This research is supported in part by the MD Anderson Cancer Center Support Grant P30 CA016672 . Maro Ohanian and Lynne V. Abruzzo analyzed the data and wrote the paper. Carlos Bueso-Ramos, Pei Lin, Chi Young Ok, and Yang O. Huh performed the pathology evaluation. Keyur Patel performed the JAK2 mutation analysis. Joseph Khoury provided cytogenetics images, Mona Lisa Alattar, Uri Rozovski, Zeev Estrov, and Jorge Cortes provided clinical information. Publisher Copyright: {\textcopyright} 2015 .",
year = "2015",
month = nov,
doi = "10.1016/j.cancergen.2015.06.004",
language = "English (US)",
volume = "208",
pages = "571--574",
journal = "Cancer Genetics",
issn = "2210-7762",
publisher = "Elsevier BV",
number = "11",
}