Acute myeloid leukemia with t(10;11): A pathological entity with distinct clinical presentation

Courtney D. DiNardo, Guilin Tang, Naveen Pemmaraju, Sa A. Wang, Allison Pike, Guillermo Garcia-Manero, Jorge Cortes, Carlos Bueso-Ramos, Hagop M. Kantarjian

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

t(10;11)(p12;q23) is a rare recurrent translocation involving the mixed lineage leukemia (MLL) gene translocation, most commonly seen in pediatric and young adult acute myeloid leukemia (AML), associated with early morbidity including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure from leukocytosis. With supportive care, first remissions are frequently attained, but patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes. Introduction: Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and monoblastic/monocytic morphology, with an increased risk of leukocytosis and leukostasis-related complications. Yet, little is known regarding the clinical presentation of adult AML patients with MLL translocations based on the specific translocation partner. Patients and Methods: Two recent AML cases with t(10;11)(p12;q23) translocations are detailed, with their shared presenting symptoms highlighted, followed by a review of the current literature. Results: The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML. A high incidence of early morbidity from leukocytosis-related complications are frequently seen, including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure, even without a true leukocytosis. Conclusion: With prompt therapy and intensive supportive care first remissions are frequently attained, however, patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalClinical Lymphoma, Myeloma and Leukemia
Volume15
Issue number1
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • AML
  • DIC
  • Leukostasis
  • MLL
  • TLS

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    DiNardo, C. D., Tang, G., Pemmaraju, N., Wang, S. A., Pike, A., Garcia-Manero, G., Cortes, J., Bueso-Ramos, C., & Kantarjian, H. M. (2015). Acute myeloid leukemia with t(10;11): A pathological entity with distinct clinical presentation. Clinical Lymphoma, Myeloma and Leukemia, 15(1), 47-51. https://doi.org/10.1016/j.clml.2014.06.022