Acute Renal Failure With Glomerular Thrombosis in a Patient With Chronic Scleroderma

Denise M. Ricker, Hari M. Sharma, Norris Stanley Nahman

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A 48-year-old woman with a 20-year history of scleroderma presented with malignant hypertension, thrombocytopenia, and acute renal failure. Renal biopsy demonstrated vascular changes consistent with scleroderma and glomerular thrombi. Her clinical course was consistent with hemolytic uremic syndromelthrombotic thrombocytopenic purpura (HUS/TTP)-like syndrome. Plasma exchange therapy was associated with an improvement in renal function and rise in platelet count. This case suggests that acute renal failure in patients with scleroderma can be associated with glomerular thrombi and may improve with plasma exchange therapy.

Original languageEnglish (US)
Pages (from-to)524-526
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Keywords

  • HUS
  • Scleroderma
  • TTP
  • acute renal failure
  • glomerular thrombi

ASJC Scopus subject areas

  • Nephrology

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