Acyl-coa dehydrogenase enzymes during early postnatal development in the rat1

James Edwin Carroll, Byron S. McGuire, Valerie F. Chancey, Katherine B. Harrison

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Fatty acid oxidation rates tend to increase with age in most developing tissues. In skeletal muscle, heart, and liver of developing rats, we measured activities of three acyl-CoA dehydrogenase enzymes, which constitute the first step in the mitochondrial p-oxida-tion sequence. In skeletal muscle, activities of all three enzymes increased with age. In heart muscle, palmityl-CoA dehydrogenase increased, while the other two enzymes changed only minimally. In liver, palmityl-CoA dehydrogenase activity steadily increased with age. Deca-noyl- and butyryl-CoA dehydrogenase also increased with age, but much more irregularly. We also examined the electrophoretic characteristics of these enzyme proteins in the three tissues. There were no changes in their electrophoretic patterns during development.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalNeonatology
Volume55
Issue number3
DOIs
StatePublished - Jan 1 1989

Fingerprint

Oxidoreductases
Palmitoyl Coenzyme A
Enzymes
Butyryl-CoA Dehydrogenase
Skeletal Muscle
Acyl-CoA Dehydrogenase
Liver
Myocardium
Fatty Acids
Proteins

Keywords

  • Acyl-CoA dehydrogenase
  • Heart
  • Liver
  • Rat
  • Skeletal muscle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

Acyl-coa dehydrogenase enzymes during early postnatal development in the rat1. / Carroll, James Edwin; McGuire, Byron S.; Chancey, Valerie F.; Harrison, Katherine B.

In: Neonatology, Vol. 55, No. 3, 01.01.1989, p. 185-190.

Research output: Contribution to journalArticle

Carroll, James Edwin ; McGuire, Byron S. ; Chancey, Valerie F. ; Harrison, Katherine B. / Acyl-coa dehydrogenase enzymes during early postnatal development in the rat1. In: Neonatology. 1989 ; Vol. 55, No. 3. pp. 185-190.
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