Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension

Tibor Fulop, Eva Jebelovszki, Nora Erdei, Tamas Szerafin, Tamas Forster, Istvan Edes, Akos Koller, Zsolt Bagi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVES - We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS - Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10 mol/L, lean:90±4%, obese:64±7%; SNP, 10 mol/L, lean:89±7%, obese:76±5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean:71±7%, obese:85±3%; SNP, lean:60±6%, obese:83±2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD:6.2±0.7%, NTG:17.2±0.9%), than in lean hypertensive patients (FMD:3.7±0.6%, NTG:13.6±1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS - These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients.

Original languageEnglish (US)
Pages (from-to)2348-2354
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2007

Fingerprint

Arterioles
Dilatation
Obesity
Nitroglycerin
Hypertension
Nitroprusside
Bradykinin
Blood Vessels
Body Mass Index
Brachial Artery
Thoracic Surgery
Tissue Donors

Keywords

  • Coronary microcirculation
  • Flow-mediated dilation
  • Hypertension
  • Nitrate
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. / Fulop, Tibor; Jebelovszki, Eva; Erdei, Nora; Szerafin, Tamas; Forster, Tamas; Edes, Istvan; Koller, Akos; Bagi, Zsolt.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 27, No. 11, 01.11.2007, p. 2348-2354.

Research output: Contribution to journalArticle

Fulop, Tibor ; Jebelovszki, Eva ; Erdei, Nora ; Szerafin, Tamas ; Forster, Tamas ; Edes, Istvan ; Koller, Akos ; Bagi, Zsolt. / Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. In: Arteriosclerosis, thrombosis, and vascular biology. 2007 ; Vol. 27, No. 11. pp. 2348-2354.
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AU - Fulop, Tibor

AU - Jebelovszki, Eva

AU - Erdei, Nora

AU - Szerafin, Tamas

AU - Forster, Tamas

AU - Edes, Istvan

AU - Koller, Akos

AU - Bagi, Zsolt

PY - 2007/11/1

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N2 - OBJECTIVES - We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS - Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10 mol/L, lean:90±4%, obese:64±7%; SNP, 10 mol/L, lean:89±7%, obese:76±5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean:71±7%, obese:85±3%; SNP, lean:60±6%, obese:83±2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD:6.2±0.7%, NTG:17.2±0.9%), than in lean hypertensive patients (FMD:3.7±0.6%, NTG:13.6±1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS - These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients.

AB - OBJECTIVES - We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS - Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10 mol/L, lean:90±4%, obese:64±7%; SNP, 10 mol/L, lean:89±7%, obese:76±5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean:71±7%, obese:85±3%; SNP, lean:60±6%, obese:83±2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD:6.2±0.7%, NTG:17.2±0.9%), than in lean hypertensive patients (FMD:3.7±0.6%, NTG:13.6±1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS - These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients.

KW - Coronary microcirculation

KW - Flow-mediated dilation

KW - Hypertension

KW - Nitrate

KW - Obesity

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