Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus

Nevin A Lambert, T. J. Teyler

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and d,l-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalNeuroscience Letters
Volume122
Issue number1
DOIs
StatePublished - Jan 14 1991
Externally publishedYes

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Inhibitory Postsynaptic Potentials
Synaptic Transmission
Adenosine
Hippocampus
Adenosine A1 Receptor Antagonists
2-Amino-5-phosphonovalerate
Synaptic Potentials
Interneurons
Neurons

Keywords

  • A Receptor
  • Monosynaptic IPSP
  • Rat hippocampal slice

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus. / Lambert, Nevin A; Teyler, T. J.

In: Neuroscience Letters, Vol. 122, No. 1, 14.01.1991, p. 50-52.

Research output: Contribution to journalArticle

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