Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

Ning Li; Thomas A. Csepe; Brian J. Hansen; Lidiya V. Sul; Anuradha Kalyanasundaram; Stanislav O. Zakharkin; Jichao Zhao; Avirup Guha; David R. Van Wagoner; Ahmet Kilic; Peter J. Mohler; Paul M. L. Janssen; Brandon J. Biesiadecki; John D. Hummel; Raul Weiss; Vadim V. Fedorov

doi:10.1161/CIRCULATIONAHA.115.021165

Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

Ning Li, Thomas A. Csepe, Brian J. Hansen, Lidiya V. Sul, Anuradha Kalyanasundaram, Stanislav O. Zakharkin, Jichao Zhao, Avirup Guha, David R. Van Wagoner, Ahmet Kilic, Peter J. Mohler, Paul M. L. Janssen, Brandon J. Biesiadecki, John D. Hummel, Raul Weiss, Vadim V. Fedorov

Cardiology

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Background: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional substrates are unclear. We tested the hypothesis that adenosine-induced AF is driven by localized reentry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (I K,Ado). Methods: We applied biatrial optical mapping and immunoblot mapping of various atrial regions to reveal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37). Results: Optical mapping of coronary-perfused atria (n=24) revealed that adenosine perfusion (10-100 mol/L) produced more significant shortening of action potential durations in RA (from 290±45 to 239±41 ms, 17.3±10.4%; P

Original language	English (US)
Pages (from-to)	486-498
Number of pages	13
Journal	Circulation
Volume	134
Issue number	6
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.115.021165 https://doi.org/10.1161/circulationaha.115.021165
State	Published - Jul 2016

Keywords

G protein-coupled inwardly rectifying potassium channels
adenosine
atrial fibrillation
optical mapping
receptor, adenosine A1
tertiapin

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Li, N., Csepe, T. A., Hansen, B. J., Sul, L. V., Kalyanasundaram, A., Zakharkin, S. O., Zhao, J., Guha, A., Wagoner, D. R. V., Kilic, A., Mohler, P. J., Janssen, P. M. L., Biesiadecki, B. J., Hummel, J. D., Weiss, R., & Fedorov, V. V. (2016). Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation, 134(6), 486-498. https://doi.org/10.1161/CIRCULATIONAHA.115.021165, https://doi.org/10.1161/circulationaha.115.021165

Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. / Li, Ning; Csepe, Thomas A.; Hansen, Brian J. et al.
In: Circulation, Vol. 134, No. 6, 07.2016, p. 486-498.

Research output: Contribution to journal › Article › peer-review

Li, N, Csepe, TA, Hansen, BJ, Sul, LV, Kalyanasundaram, A, Zakharkin, SO, Zhao, J, Guha, A, Wagoner, DRV, Kilic, A, Mohler, PJ, Janssen, PML, Biesiadecki, BJ, Hummel, JD, Weiss, R & Fedorov, VV 2016, 'Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart', Circulation, vol. 134, no. 6, pp. 486-498. https://doi.org/10.1161/CIRCULATIONAHA.115.021165, https://doi.org/10.1161/circulationaha.115.021165

Li N, Csepe TA, Hansen BJ, Sul LV, Kalyanasundaram A, Zakharkin SO et al. Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation. 2016 Jul;134(6):486-498. doi: 10.1161/CIRCULATIONAHA.115.021165, 10.1161/circulationaha.115.021165

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title = "Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart",

abstract = "Background: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left atria (LA) in patients, but the underlying molecular and functional substrates are unclear. We tested the hypothesis that adenosine-induced AF is driven by localized reentry in RA areas with highest expression of adenosine A1 receptor and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (I K,Ado). Methods: We applied biatrial optical mapping and immunoblot mapping of various atrial regions to reveal the mechanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37). Results: Optical mapping of coronary-perfused atria (n=24) revealed that adenosine perfusion (10-100 mol/L) produced more significant shortening of action potential durations in RA (from 290±45 to 239±41 ms, 17.3±10.4%; P",

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author = "Ning Li and Csepe, {Thomas A.} and Hansen, {Brian J.} and Sul, {Lidiya V.} and Anuradha Kalyanasundaram and Zakharkin, {Stanislav O.} and Jichao Zhao and Avirup Guha and Wagoner, {David R. Van} and Ahmet Kilic and Mohler, {Peter J.} and Janssen, {Paul M. L.} and Biesiadecki, {Brandon J.} and Hummel, {John D.} and Raul Weiss and Fedorov, {Vadim V.}",

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doi = "10.1161/CIRCULATIONAHA.115.021165",

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AU - Csepe, Thomas A.

AU - Hansen, Brian J.

AU - Sul, Lidiya V.

AU - Kalyanasundaram, Anuradha

AU - Zakharkin, Stanislav O.

AU - Zhao, Jichao

AU - Guha, Avirup

AU - Wagoner, David R. Van

AU - Kilic, Ahmet

AU - Mohler, Peter J.

AU - Janssen, Paul M. L.

AU - Biesiadecki, Brandon J.

AU - Hummel, John D.

AU - Weiss, Raul

AU - Fedorov, Vadim V.

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Adenosine-Induced Atrial FibrillationClinical Perspective: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

Abstract

Keywords

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