Adenovirus internalization and infection require dynamin

Kena Wang, Shuang Huang, Archana Kapoor-Munshi, Glen Nemerow

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


The cell receptors that facilitate adenovirus internalization into cells have been identified; however, the infectious pathway of virus entry has not been established. Adenovirus entry and infection were examined in HeLa cells lacking or overexpressing mutant dynamin, a protein that specifically regulates clathrin-mediated endocytosis. Expression of mutant dynamin significantly reduced adenovirus internalization and gene delivery, indicating a functional requirement for this molecule. These findings are consistent with virus entry via the clathrin-coated pit pathway.

Original languageEnglish (US)
Pages (from-to)3455-3458
Number of pages4
JournalJournal of Virology
Issue number4
StatePublished - Apr 1998
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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