Adenovirus internalization and infection require dynamin

Kena Wang, Shuang Huang, Archana Kapoor-Munshi, Glen Nemerow

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

The cell receptors that facilitate adenovirus internalization into cells have been identified; however, the infectious pathway of virus entry has not been established. Adenovirus entry and infection were examined in HeLa cells lacking or overexpressing mutant dynamin, a protein that specifically regulates clathrin-mediated endocytosis. Expression of mutant dynamin significantly reduced adenovirus internalization and gene delivery, indicating a functional requirement for this molecule. These findings are consistent with virus entry via the clathrin-coated pit pathway.

Original languageEnglish (US)
Pages (from-to)3455-3458
Number of pages4
JournalJournal of Virology
Volume72
Issue number4
StatePublished - Apr 1 1998

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Dynamins
Adenoviridae Infections
Virus Internalization
Clathrin
Adenoviridae
clathrin
Endocytosis
HeLa Cells
infection
viruses
mutants
endocytosis
cells
gene transfer
Genes
receptors
Proteins
dynamins
proteins
adenovirus receptor

ASJC Scopus subject areas

  • Immunology

Cite this

Wang, K., Huang, S., Kapoor-Munshi, A., & Nemerow, G. (1998). Adenovirus internalization and infection require dynamin. Journal of Virology, 72(4), 3455-3458.

Adenovirus internalization and infection require dynamin. / Wang, Kena; Huang, Shuang; Kapoor-Munshi, Archana; Nemerow, Glen.

In: Journal of Virology, Vol. 72, No. 4, 01.04.1998, p. 3455-3458.

Research output: Contribution to journalArticle

Wang, K, Huang, S, Kapoor-Munshi, A & Nemerow, G 1998, 'Adenovirus internalization and infection require dynamin', Journal of Virology, vol. 72, no. 4, pp. 3455-3458.
Wang K, Huang S, Kapoor-Munshi A, Nemerow G. Adenovirus internalization and infection require dynamin. Journal of Virology. 1998 Apr 1;72(4):3455-3458.
Wang, Kena ; Huang, Shuang ; Kapoor-Munshi, Archana ; Nemerow, Glen. / Adenovirus internalization and infection require dynamin. In: Journal of Virology. 1998 ; Vol. 72, No. 4. pp. 3455-3458.
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