TY - JOUR
T1 - Adequacy of Early Empiric Antibiotic Treatment and Survival in Severe Sepsis
T2 - Experience from the MONARCS Trial
AU - MacArthur, Rodger David
AU - Miller, Mark
AU - Albertson, Timothy
AU - Panacek, Edward
AU - Johnson, David
AU - Teoh, Leah
AU - Barchuk, William
PY - 2004/1/15
Y1 - 2004/1/15
N2 - As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P < .001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.
AB - As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P < .001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.
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U2 - 10.1086/379825
DO - 10.1086/379825
M3 - Article
C2 - 14699463
AN - SCOPUS:1642456548
SN - 1058-4838
VL - 38
SP - 284
EP - 288
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -