Adhesion Reformation

Reduction by the Use of Interceed (TC7) Plus Heparin

Michael Peter Diamond, Cary B. Linsky, Tim Cunningham, Lola Kamp, Eli Pines, Alan H. Decherney, Gere S. Dizerega

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Adhesions frequently develop after surgical procedures. Several groups have demonstrated that reduction of adhesion reformation is more difficult than reduction of adhesion formation. Previous studies have demonstrated the efficacy of Interceed (TC7) (oxidized regenerated cellulose) plus heparin in reducing adhesion formation. This study evaluates the efficacy of this combination in limiting adhesion reformation. Adhesions were created using a previously standardized rabbit uterine horn model. After adhesiolysis, rabbits were assigned randomly to one of four groups: control, Interceed (TC7) alone, Interceed (TC7) plus 500 USP units heparin/horn, and Interceed (TC7) plus 1000 USP units heparin/horn. Adhesion reformation was evaluated 2 weeks later. Combination of the Interceed (TC7) barrier plus heparin resulted in a significant reduction of the adhesion reformation scores. It is concluded that Interceed (TC7) plus heparin is efficacious in reduction of both adhesion formation and adhesion reformation.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Gynecologic Surgery
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1991

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Heparin
Horns
oxidized cellulose
Rabbits
INTERCEED
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

Diamond, M. P., Linsky, C. B., Cunningham, T., Kamp, L., Pines, E., Decherney, A. H., & Dizerega, G. S. (1991). Adhesion Reformation: Reduction by the Use of Interceed (TC7) Plus Heparin. Journal of Gynecologic Surgery, 7(1), 1-6. https://doi.org/10.1089/gyn.1991.7.1

Adhesion Reformation : Reduction by the Use of Interceed (TC7) Plus Heparin. / Diamond, Michael Peter; Linsky, Cary B.; Cunningham, Tim; Kamp, Lola; Pines, Eli; Decherney, Alan H.; Dizerega, Gere S.

In: Journal of Gynecologic Surgery, Vol. 7, No. 1, 01.01.1991, p. 1-6.

Research output: Contribution to journalArticle

Diamond, MP, Linsky, CB, Cunningham, T, Kamp, L, Pines, E, Decherney, AH & Dizerega, GS 1991, 'Adhesion Reformation: Reduction by the Use of Interceed (TC7) Plus Heparin', Journal of Gynecologic Surgery, vol. 7, no. 1, pp. 1-6. https://doi.org/10.1089/gyn.1991.7.1
Diamond, Michael Peter ; Linsky, Cary B. ; Cunningham, Tim ; Kamp, Lola ; Pines, Eli ; Decherney, Alan H. ; Dizerega, Gere S. / Adhesion Reformation : Reduction by the Use of Interceed (TC7) Plus Heparin. In: Journal of Gynecologic Surgery. 1991 ; Vol. 7, No. 1. pp. 1-6.
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