TY - JOUR
T1 - Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
AU - Bundy, Vanessa
AU - Johnson, Maribeth
AU - Gutin, Bernard
AU - Zhu, Haidong
AU - Stallmann-Jorgensen, Inger
AU - Dong, Yanbin
N1 - Funding Information:
We would like to thank the adolescents who participated in this study, the local high schools and the Richmond and Columbia Boards of Education who facilitated subject recruitment. Additionally, we would like to acknowledge Dr. Paule Barbeau for study design assistance and support, Dr. Joe Cannon for performing the leptin assays, and Ms. Elizabeth Stewart for data management. Funding for this study was provided by National Institutes of Health (NIH) HL64157, NIH 1T32HL076146-01.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Objectives: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships. Methods: Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays. Results: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p=0.0017) and black girls had the highest leptin (p=0.0164). Percent BF and leptin were positively correlated (p=0.0164). The %BF-leptin relationship was stronger in boys than girls (p<0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p=0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender. Conclusion: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
AB - Objectives: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships. Methods: Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays. Results: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p=0.0017) and black girls had the highest leptin (p=0.0164). Percent BF and leptin were positively correlated (p=0.0164). The %BF-leptin relationship was stronger in boys than girls (p<0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p=0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender. Conclusion: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
KW - adiponectin
KW - adolescents
KW - leptin
KW - percent body fat.
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U2 - 10.1515/JPEM.2011.036
DO - 10.1515/JPEM.2011.036
M3 - Article
C2 - 21648277
AN - SCOPUS:79955519186
SN - 0334-018X
VL - 24
SP - 119
EP - 124
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 3-4
ER -
