Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race

Vanessa Bundy, Maribeth Johnson, Bernard Gutin, Haidong Zhu, Inger Stallmann-Jorgensen, Yanbin Dong

Research output: Contribution to journalArticle

2 Scopus citations


Objectives: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships. Methods: Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays. Results: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p=0.0017) and black girls had the highest leptin (p=0.0164). Percent BF and leptin were positively correlated (p=0.0164). The %BF-leptin relationship was stronger in boys than girls (p<0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p=0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender. Conclusion: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number3-4
Publication statusPublished - Apr 1 2011



  • adiponectin
  • adolescents
  • leptin
  • percent body fat.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this