Adiposity Is Related to Gender Differences in Impaired Stress-Induced Pressure Natriuresis

Gregory A Harshfield, Martha E. Wilson, Kathryn McLeod, Coral Hanevold, Gaston K. Kapuku, Lynne Mackey, Delores Gillis, Lesley Edmonds

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The purpose of this study was to determine if there are gender differences in stress-induced pressure natriuresis and to examine the effects of adiposity on these differences. The subjects were 151 boys and 141 girls 15 to 18 years of age who underwent a 5-hour stress protocol (2-hour prestress, 1-hour stress, 2-hour poststress) after being brought into similar levels of sodium balance. The gender-by-condition interaction was significant for systolic and diastolic blood pressure (P=0.001 for both), and the effect of condition was significant for sodium excretion (P=0.001). Systolic blood pressure was higher for boys throughout the protocol (P=0.001 for each) and correlated with body mass index at each condition (range in r=0.28 to 0.35; P<0.001 for each). Hemodynamically, in boys body mass index was correlated with cardiac output during stress (r=0.23; P=0.006), which was correlated with systolic blood pressure (r=0.21; P=0.01). With respect to natriuresis, body mass index was inversely correlated with sodium excretion during stress (r=-0.22; P=0.008) and positively correlated with angiotensin II in a subsample of boys (n=89: r=0.31; P=0.003). The inverse correlation between angiotensin II and sodium excretion during stress approached significance (r=-0.17; P<0.06). Similar results were not observed for girls. In conclusion, gender differences in stress-induced pressure natriuresis appear to be related to the influence of adiposity on both blood pressure and natriuresis.

Original languageEnglish (US)
Pages (from-to)1082-1086
Number of pages5
Issue number6
StatePublished - Dec 2003


  • Blood pressure
  • Gender
  • Hypertension, sodium-dependent
  • Natriuresis
  • Obesity
  • Sodium
  • Stress

ASJC Scopus subject areas

  • Internal Medicine


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