Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial

Alex Nogueira Haas, Carina Mac Iel Silva-Boghossian, Ana Paula Colombo, Cristiano Susin, Jasim M. Albandar, Rui Vicente Oppermann, Cassiano Kuchenbecker Rösing

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. Methods: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. Results: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. Conclusions: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. Clinical significance: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.

Original languageEnglish (US)
Pages (from-to)556-563
Number of pages8
JournalJournal of Dentistry
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2012

Fingerprint

Root Planing
Aggressive Periodontitis
Azithromycin
Dental Scaling
Randomized Controlled Trials
Placebos
Actinomyces
Streptococcus gordonii
Eikenella corrodens
Capnocytophaga
Veillonella
Treponema denticola
Fusobacterium
Fusobacterium nucleatum
Eubacterium
DNA
Therapeutics
Bacteria

Keywords

  • Adolescents/young-adults
  • Aggressive periodontitis
  • Azithromycin
  • Checkerboard DNA-DNA hybridization
  • Randomized controlled trial
  • Systemic antibiotics

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Haas, A. N., Silva-Boghossian, C. M. I., Colombo, A. P., Susin, C., Albandar, J. M., Oppermann, R. V., & Rösing, C. K. (2012). Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial. Journal of Dentistry, 40(7), 556-563. https://doi.org/10.1016/j.jdent.2012.03.004

Adjunctive azithromycin in the treatment of aggressive periodontitis : Microbiological findings of a 12-month randomized clinical trial. / Haas, Alex Nogueira; Silva-Boghossian, Carina Mac Iel; Colombo, Ana Paula; Susin, Cristiano; Albandar, Jasim M.; Oppermann, Rui Vicente; Rösing, Cassiano Kuchenbecker.

In: Journal of Dentistry, Vol. 40, No. 7, 01.07.2012, p. 556-563.

Research output: Contribution to journalArticle

Haas, AN, Silva-Boghossian, CMI, Colombo, AP, Susin, C, Albandar, JM, Oppermann, RV & Rösing, CK 2012, 'Adjunctive azithromycin in the treatment of aggressive periodontitis: Microbiological findings of a 12-month randomized clinical trial', Journal of Dentistry, vol. 40, no. 7, pp. 556-563. https://doi.org/10.1016/j.jdent.2012.03.004
Haas, Alex Nogueira ; Silva-Boghossian, Carina Mac Iel ; Colombo, Ana Paula ; Susin, Cristiano ; Albandar, Jasim M. ; Oppermann, Rui Vicente ; Rösing, Cassiano Kuchenbecker. / Adjunctive azithromycin in the treatment of aggressive periodontitis : Microbiological findings of a 12-month randomized clinical trial. In: Journal of Dentistry. 2012 ; Vol. 40, No. 7. pp. 556-563.
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abstract = "Objectives: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. Methods: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. Results: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. Conclusions: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. Clinical significance: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.",
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