Adrenal androgen excess in hyperandrogenism

Relation to age and body mass

Carlos Morán, Eric Knochenhauer, Larry R. Boots, Ricardo Azziz

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Objective: To determine whether DHEAS levels in hyperandrogenic (HA) women retain the normal age-related decrease. Design: Prospective study. Setting: Academic tertiary care medical center. Patient(s): One hundred forty-five HA patients with hirsutism and/or oligo-ovulation and 53 healthy women. Intervention(s): Blood samples were obtained on days 3-8 of the menstrual cycle or after an IM progesterone-induced withdrawal bleed. Main Outcome Measure(s): Serum samples were assayed for progesterone, total testosterone, sex hormone-binding globulin, free testosterone, and DHEAS. Result(s): Controls and HA patients were similar in body mass index and age. A negative correlation between DHEAS levels and age, but not body mass index, was found among controls. In HA patients, DHEAS levels decreased with age. Dehydroepiandrosterone sulfate levels correlated with the hirsutism score in HA patients. When HA patients were subdivided into those with low, middle, and high DHEAS levels, those with low DHEAS levels were older and weighed more than those with high DHEAS levels. Conclusion(s): The negative association between DHEAS levels and age is preserved in HA women. Hyperandrogenic patients with high DHEAS levels are younger, thinner, and more hirsute than those with lower DHEAS levels. These findings suggest that the diagnosis of adrenal androgen excess in HA patients may require the use of age-adjusted normative values.

Original languageEnglish (US)
Pages (from-to)671-674
Number of pages4
JournalFertility and sterility
Volume71
Issue number4
DOIs
StatePublished - Apr 1 1999

Fingerprint

Hyperandrogenism
Androgens
Hirsutism
Progesterone
Testosterone
Body Mass Index
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Menstrual Cycle
Ovulation
Tertiary Care Centers
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Adrenal
  • Aging
  • Androgens
  • Hirsutism
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Adrenal androgen excess in hyperandrogenism : Relation to age and body mass. / Morán, Carlos; Knochenhauer, Eric; Boots, Larry R.; Azziz, Ricardo.

In: Fertility and sterility, Vol. 71, No. 4, 01.04.1999, p. 671-674.

Research output: Contribution to journalArticle

Morán, Carlos ; Knochenhauer, Eric ; Boots, Larry R. ; Azziz, Ricardo. / Adrenal androgen excess in hyperandrogenism : Relation to age and body mass. In: Fertility and sterility. 1999 ; Vol. 71, No. 4. pp. 671-674.
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