Adrenal androgen production in response to adrenocorticotropin infusions in men

C. R. Parker, Ricardo Azziz, H. D. Potter, L. R. Boots

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The responses of several adrenal steroids to adrenocorticotropin (ACTH) were investigated in a group of healthy young men. The protocol consisted of overnight adrenal suppression with dexamethasone followed by 1 hr infusions of ACTH in increasing (4X) doses ranging from 30 - 30,720 ng/1.5M2 followed by 0.25 mg ACTH/1.5M2. Whereas cortisol, androstenedione and androstenediol concentrations tended to plateau at the higher ACTH infusion rates, those of dehydroepiandrosterone (DHEA) and 17-hydroxyprogesterone (17-OH P) did not. The cortisol concentration achieved after the highest dose of ACTH was over 50 fold higher than that at baseline. DHEA levels rose to values about 13 times baseline whereas the other steroids increased to lesser extents (3-5 fold). The ACTH infusion rate required to significantly increase each steroid over the baseline level was extrapolated from dose response curves and was considered to be an index of the sensitivity of each steroid to ACTH. Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17- OH P.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalEndocrine Research
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1996

Fingerprint

Adrenocorticotropic Hormone
Androgens
Dehydroepiandrosterone
Androstenediol
Steroids
Hydrocortisone
Androstenedione
17-alpha-Hydroxyprogesterone
Dexamethasone

ASJC Scopus subject areas

  • Endocrinology

Cite this

Adrenal androgen production in response to adrenocorticotropin infusions in men. / Parker, C. R.; Azziz, Ricardo; Potter, H. D.; Boots, L. R.

In: Endocrine Research, Vol. 22, No. 4, 01.01.1996, p. 717-722.

Research output: Contribution to journalArticle

Parker, C. R. ; Azziz, Ricardo ; Potter, H. D. ; Boots, L. R. / Adrenal androgen production in response to adrenocorticotropin infusions in men. In: Endocrine Research. 1996 ; Vol. 22, No. 4. pp. 717-722.
@article{9fc90cd66cd9437bb65c4d5191cb7398,
title = "Adrenal androgen production in response to adrenocorticotropin infusions in men",
abstract = "The responses of several adrenal steroids to adrenocorticotropin (ACTH) were investigated in a group of healthy young men. The protocol consisted of overnight adrenal suppression with dexamethasone followed by 1 hr infusions of ACTH in increasing (4X) doses ranging from 30 - 30,720 ng/1.5M2 followed by 0.25 mg ACTH/1.5M2. Whereas cortisol, androstenedione and androstenediol concentrations tended to plateau at the higher ACTH infusion rates, those of dehydroepiandrosterone (DHEA) and 17-hydroxyprogesterone (17-OH P) did not. The cortisol concentration achieved after the highest dose of ACTH was over 50 fold higher than that at baseline. DHEA levels rose to values about 13 times baseline whereas the other steroids increased to lesser extents (3-5 fold). The ACTH infusion rate required to significantly increase each steroid over the baseline level was extrapolated from dose response curves and was considered to be an index of the sensitivity of each steroid to ACTH. Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17- OH P.",
author = "Parker, {C. R.} and Ricardo Azziz and Potter, {H. D.} and Boots, {L. R.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1080/07435809609043767",
language = "English (US)",
volume = "22",
pages = "717--722",
journal = "Endocrine Research",
issn = "0743-5800",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Adrenal androgen production in response to adrenocorticotropin infusions in men

AU - Parker, C. R.

AU - Azziz, Ricardo

AU - Potter, H. D.

AU - Boots, L. R.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The responses of several adrenal steroids to adrenocorticotropin (ACTH) were investigated in a group of healthy young men. The protocol consisted of overnight adrenal suppression with dexamethasone followed by 1 hr infusions of ACTH in increasing (4X) doses ranging from 30 - 30,720 ng/1.5M2 followed by 0.25 mg ACTH/1.5M2. Whereas cortisol, androstenedione and androstenediol concentrations tended to plateau at the higher ACTH infusion rates, those of dehydroepiandrosterone (DHEA) and 17-hydroxyprogesterone (17-OH P) did not. The cortisol concentration achieved after the highest dose of ACTH was over 50 fold higher than that at baseline. DHEA levels rose to values about 13 times baseline whereas the other steroids increased to lesser extents (3-5 fold). The ACTH infusion rate required to significantly increase each steroid over the baseline level was extrapolated from dose response curves and was considered to be an index of the sensitivity of each steroid to ACTH. Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17- OH P.

AB - The responses of several adrenal steroids to adrenocorticotropin (ACTH) were investigated in a group of healthy young men. The protocol consisted of overnight adrenal suppression with dexamethasone followed by 1 hr infusions of ACTH in increasing (4X) doses ranging from 30 - 30,720 ng/1.5M2 followed by 0.25 mg ACTH/1.5M2. Whereas cortisol, androstenedione and androstenediol concentrations tended to plateau at the higher ACTH infusion rates, those of dehydroepiandrosterone (DHEA) and 17-hydroxyprogesterone (17-OH P) did not. The cortisol concentration achieved after the highest dose of ACTH was over 50 fold higher than that at baseline. DHEA levels rose to values about 13 times baseline whereas the other steroids increased to lesser extents (3-5 fold). The ACTH infusion rate required to significantly increase each steroid over the baseline level was extrapolated from dose response curves and was considered to be an index of the sensitivity of each steroid to ACTH. Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17- OH P.

UR - http://www.scopus.com/inward/record.url?scp=12644289311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12644289311&partnerID=8YFLogxK

U2 - 10.1080/07435809609043767

DO - 10.1080/07435809609043767

M3 - Article

VL - 22

SP - 717

EP - 722

JO - Endocrine Research

JF - Endocrine Research

SN - 0743-5800

IS - 4

ER -