Adrenal involvement in captopril-induced potentiation of morphine analgesia

Sumantra Das, Tapan K. Chatterjee, Jagat J. Ghosh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The involvement of the angiotensin-adrenal system as a possible mechanism in the potentiation of morphine analgesia by the angiotensin-converting enzyme inhibitor, captopril (SQ 14225), was studied in rats. Captopril pretreatment sensitized the animals to the analgesic effects of morphine while angiotensin II exerted an attenuating influence. These effects, however, were not demonstrable in adrenalectomized animals. Although captopril could inhibit the plasma angiotensin-converting enzyme activity, it appeared to have no significant effect on the brain enzyme. It has been suggested that the effects of captopril and angiotensin II on morphine analgesia are mediated indirectly through their effects on adrenal function.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalEuropean Journal of Pharmacology
Volume85
Issue number2
DOIs
Publication statusPublished - Nov 19 1982

    Fingerprint

Keywords

  • Adrenal
  • Analgesia
  • Angiotensin II
  • Captopril
  • Enkephalinase
  • Morphine

ASJC Scopus subject areas

  • Pharmacology

Cite this