Adult hemoglobin levels in newborn babies from different countries and in babies with some significant hemoglobinopathies

F. Kutlar, Abdullah Kutlar, Y. C. Gu, T. H.J. Huisman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The level of adult hemoglobin (Hb A, Hb S, Hb C, Hb E) was determined in cord blood samples of 66 Black babies (41 with four α-globin genes; 25 with two α-globin genes) with Hb A, of 51 SS, 7 CC, and 6 EE babies, of 359 babies from Mediterranean countries, and 197 babies from Japan and China. Methodology involved high-performance liquid chromatographic procedures, which are considered most accurate because of a complete separation of Hb F (or γ chians) and the adult hemoglobins (or β(A) or β(X) chains). The presence of an α2-thalassemia homozygosity (-α/-α versus αα/αα) did not affect the average Hb A level. The levels of Hb S and Hb E in homozygous Hb S or Hb E babies were about one-third lower than the Hb A of the normal baby, while that of Hb C in homozygous Hb C babies was not decreased. The average level of Hb A in Chinese (50 babies) and Japanese (147 babies) was about 16.0%, which was significantly lower than the average level of 19.0% in newborns of Italian (221 babies), Yugoslavian (68 babies), and Turkish (70 babies) origin.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalActa Haematologica
Volume78
Issue number1
DOIs
StatePublished - Jan 1 1987

Fingerprint

Hemoglobinopathies
Globins
Hemoglobins
Thalassemia
Fetal Blood
Genes
China
Japan

ASJC Scopus subject areas

  • Hematology

Cite this

Adult hemoglobin levels in newborn babies from different countries and in babies with some significant hemoglobinopathies. / Kutlar, F.; Kutlar, Abdullah; Gu, Y. C.; Huisman, T. H.J.

In: Acta Haematologica, Vol. 78, No. 1, 01.01.1987, p. 28-32.

Research output: Contribution to journalArticle

@article{71affec167ff4cebbb08784353ba56b0,
title = "Adult hemoglobin levels in newborn babies from different countries and in babies with some significant hemoglobinopathies",
abstract = "The level of adult hemoglobin (Hb A, Hb S, Hb C, Hb E) was determined in cord blood samples of 66 Black babies (41 with four α-globin genes; 25 with two α-globin genes) with Hb A, of 51 SS, 7 CC, and 6 EE babies, of 359 babies from Mediterranean countries, and 197 babies from Japan and China. Methodology involved high-performance liquid chromatographic procedures, which are considered most accurate because of a complete separation of Hb F (or γ chians) and the adult hemoglobins (or β(A) or β(X) chains). The presence of an α2-thalassemia homozygosity (-α/-α versus αα/αα) did not affect the average Hb A level. The levels of Hb S and Hb E in homozygous Hb S or Hb E babies were about one-third lower than the Hb A of the normal baby, while that of Hb C in homozygous Hb C babies was not decreased. The average level of Hb A in Chinese (50 babies) and Japanese (147 babies) was about 16.0{\%}, which was significantly lower than the average level of 19.0{\%} in newborns of Italian (221 babies), Yugoslavian (68 babies), and Turkish (70 babies) origin.",
author = "F. Kutlar and Abdullah Kutlar and Gu, {Y. C.} and Huisman, {T. H.J.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1159/000205831",
language = "English (US)",
volume = "78",
pages = "28--32",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Adult hemoglobin levels in newborn babies from different countries and in babies with some significant hemoglobinopathies

AU - Kutlar, F.

AU - Kutlar, Abdullah

AU - Gu, Y. C.

AU - Huisman, T. H.J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The level of adult hemoglobin (Hb A, Hb S, Hb C, Hb E) was determined in cord blood samples of 66 Black babies (41 with four α-globin genes; 25 with two α-globin genes) with Hb A, of 51 SS, 7 CC, and 6 EE babies, of 359 babies from Mediterranean countries, and 197 babies from Japan and China. Methodology involved high-performance liquid chromatographic procedures, which are considered most accurate because of a complete separation of Hb F (or γ chians) and the adult hemoglobins (or β(A) or β(X) chains). The presence of an α2-thalassemia homozygosity (-α/-α versus αα/αα) did not affect the average Hb A level. The levels of Hb S and Hb E in homozygous Hb S or Hb E babies were about one-third lower than the Hb A of the normal baby, while that of Hb C in homozygous Hb C babies was not decreased. The average level of Hb A in Chinese (50 babies) and Japanese (147 babies) was about 16.0%, which was significantly lower than the average level of 19.0% in newborns of Italian (221 babies), Yugoslavian (68 babies), and Turkish (70 babies) origin.

AB - The level of adult hemoglobin (Hb A, Hb S, Hb C, Hb E) was determined in cord blood samples of 66 Black babies (41 with four α-globin genes; 25 with two α-globin genes) with Hb A, of 51 SS, 7 CC, and 6 EE babies, of 359 babies from Mediterranean countries, and 197 babies from Japan and China. Methodology involved high-performance liquid chromatographic procedures, which are considered most accurate because of a complete separation of Hb F (or γ chians) and the adult hemoglobins (or β(A) or β(X) chains). The presence of an α2-thalassemia homozygosity (-α/-α versus αα/αα) did not affect the average Hb A level. The levels of Hb S and Hb E in homozygous Hb S or Hb E babies were about one-third lower than the Hb A of the normal baby, while that of Hb C in homozygous Hb C babies was not decreased. The average level of Hb A in Chinese (50 babies) and Japanese (147 babies) was about 16.0%, which was significantly lower than the average level of 19.0% in newborns of Italian (221 babies), Yugoslavian (68 babies), and Turkish (70 babies) origin.

UR - http://www.scopus.com/inward/record.url?scp=0023635203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023635203&partnerID=8YFLogxK

U2 - 10.1159/000205831

DO - 10.1159/000205831

M3 - Article

C2 - 3116804

AN - SCOPUS:0023635203

VL - 78

SP - 28

EP - 32

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 1

ER -