Adult pilocytic astrocytoma in the molecular era: A comprehensive review

Timothy A. Gregory, Lyndon B. Chumbley, John W. Henson, Brett J. Theeler

Research output: Contribution to journalReview articlepeer-review

Abstract

Adult pilocytic astrocytoma (PA) is less prevalent than pediatric PA and is associated with a worse prognosis. In a literature review, we found that 88.3% of the molecular alterations in adult PA are associated with MAPK pathway dysregulation. The most common alterations are fusions of BRAF. Understanding of the mechanisms underlying this pathway has evolved substantially, heralding advancements in specific targeted therapy. Here, we review clinical and molecular features of adult PA, characteristics predicting aggressive behavior and approaches to standard and investigational therapies. We highlight epigenetic profiling and integrated diagnosis as an essential component of classifying PA.

Original languageEnglish (US)
Article numberCNS68
JournalCNS oncology
Volume10
Issue number1
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • BRAF
  • MAPK pathway
  • adult
  • pilocytic astrocytoma
  • targeted therapy

ASJC Scopus subject areas

  • Medicine(all)

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