Adult T-cell leukemia/lymphoma: A rare case in the USA and review of the literature

W. G. Brick, Y. Nalamolu, A. P. Jillella, R. E. Burgess, A. M. Kallab

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Adult T-cell leukemia/lymphoma (ATLL), in its acute stage, is a uniformly fatal disease. ATLL is caused by the human T-cell lymphotropic virus I (HTLV-1), a retrovirus endemic in numerous areas throughout the world including Japan, the Caribbean, Central and South America and certain areas of the United States. Although the progression from HTLV-1 carrier status to ATLL occurs only rarely, ATLL is incurable and thus prevention of HTLV-1 transmission should be a primary goal. With the development of new anti-retroviral and monoclonal therapies, there exist potential cures or at least prolonged remissions for patients diagnosed with ATLL. We present a case of ATLL that, to our knowledge, is only the third reported case in Georgia. In addition, we present a brief review of the literature, including potential new treatment regimens that appear to have promise in the treatment of ATLL.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalLeukemia and Lymphoma
Volume43
Issue number1
DOIs
StatePublished - Mar 25 2002

Keywords

  • ATLL
  • HTLV-I
  • Leukemia
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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