Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells

Girish Venkataraman, Jonathan Berkowitz, John C. Morris, John Edward Janik, Mark A. Raffeld, Stefania Pittaluga

Research output: Contribution to journalArticle

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Abstract

Hodgkin-like cells have been described in a variety of non-Hodgkin lymphomas including chronic lymphocytic leukemia and peripheral T-cell lymphoma. There have been rare reports in the Japanese population of human T-cell lymphotrophic virus-1-associated adult T-cell leukemia/lymphoma harboring Hodgkin-like cells; however, no similar cases have been described in Western patients. We report a 53-year-old African American man who presented with progressive weakness and lethargy, and was found to have generalized lymphadenopathy and hypercalcemia. A lymph node biopsy showed involvement by adult T-cell leukemia/lymphoma with scattered Epstein-Barr virus-positive cells, some of which resembled Hodgkin cells that had a B-cell phenotype, consistent with an Epstein-Barr virus-lymphoproliferative disorder. The patient had stage 4 disease with bone marrow involvement. In light of the associated B-cell lymphoproliferative process, the patient was treated with 6 cycles of intensive chemotherapy that targeted both the adult T-cell leukemia/lymphoma and the Epstein-Barr virus-lymphoproliferative disorder that resulted in a complete response. An awareness of the association of Epstein-Barr virus- lymphoproliferative disorder with Hodgkin-like cells in the context of adult T-cell leukemia/lymphoma is necessary to avoid potential misdiagnosis and to aid in therapeutic decisions.

Original languageEnglish (US)
Pages (from-to)1042-1046
Number of pages5
JournalHuman Pathology
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2011

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Adult T Cell Leukemia Lymphoma
Human Herpesvirus 4
Hodgkin Disease
Lymphoproliferative Disorders
B-Lymphocytes
Bone Marrow Diseases
Peripheral T-Cell Lymphoma
Lethargy
Hypercalcemia
B-Cell Chronic Lymphocytic Leukemia
Diagnostic Errors
African Americans
Non-Hodgkin's Lymphoma
Lymph Nodes
Viruses
T-Lymphocytes
Phenotype
Biopsy
Drug Therapy
Population

Keywords

  • Adult T-Cell Leukemia/Lymphoma
  • Epstein-Barr Virus
  • Flow Cytometry
  • Hodgkin-Like
  • Human T-Cell
  • Immunohistochemistry
  • Lymphotrophic Virus-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Venkataraman, G., Berkowitz, J., Morris, J. C., Janik, J. E., Raffeld, M. A., & Pittaluga, S. (2011). Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells. Human Pathology, 42(7), 1042-1046. https://doi.org/10.1016/j.humpath.2010.10.014

Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells. / Venkataraman, Girish; Berkowitz, Jonathan; Morris, John C.; Janik, John Edward; Raffeld, Mark A.; Pittaluga, Stefania.

In: Human Pathology, Vol. 42, No. 7, 01.07.2011, p. 1042-1046.

Research output: Contribution to journalArticle

Venkataraman, G, Berkowitz, J, Morris, JC, Janik, JE, Raffeld, MA & Pittaluga, S 2011, 'Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells', Human Pathology, vol. 42, no. 7, pp. 1042-1046. https://doi.org/10.1016/j.humpath.2010.10.014
Venkataraman G, Berkowitz J, Morris JC, Janik JE, Raffeld MA, Pittaluga S. Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells. Human Pathology. 2011 Jul 1;42(7):1042-1046. https://doi.org/10.1016/j.humpath.2010.10.014
Venkataraman, Girish ; Berkowitz, Jonathan ; Morris, John C. ; Janik, John Edward ; Raffeld, Mark A. ; Pittaluga, Stefania. / Adult T-cell leukemia/lymphoma with Epstein-Barr virus-positive Hodgkin-like cells. In: Human Pathology. 2011 ; Vol. 42, No. 7. pp. 1042-1046.
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